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PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells
文献类型：期刊论文
| 作者 | Jiang, Yuhui; Li, Xinjian; Yang, Weiwei; Hawke, David H.; Zheng, Yanhua; Xia, Yan; Aldape, Kenneth; Wei, Chongyang; Guo, Fang; Chen, Yan（陈雁）
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| 刊名 | MOLECULAR CELL
 |
| 出版日期 | 2014 |
| 卷号 | 53期号:1页码:75-87 |
| 英文摘要 | Tumor-specific pyruvate kinase M2 (PKM2) is instrumental in both aerobic glycolysis and gene transcription. PKM2 regulates G1-S phase transition by controlling cyclin D1 expression. However, it is not known whether PKM2 directly controls cell-cycle progression. We show here that PKM2, but not PKM1, binds to the spindle checkpoint protein Bub3 during mitosis and phosphorylates Bub3 at Y207. This phosphorylation is required for Bub3-Bub1 complex recruitment to kinetochores, where it interacts with Blinkin and is essential for correct kinetochore-microtubule attachment, mitotic/spindle-assembly checkpoint, accurate chromosome segregation, cell survival and proliferation, and active EGF receptor-induced brain tumorigenesis. In addition, the level of Bub3 Y207 phosphorylation correlated with histone H3-S10 phosphorylation in human glioblastoma specimens and with glioblastoma prognosis. These findings highlight the role of PKM2 as a protein kinase controlling the fidelity of chromosome segregation, cell-cycle progression, and tumorigenesis. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | PYRUVATE-KINASE M2 ; SPINDLE-ASSEMBLY CHECKPOINT ; MITOTIC CHECKPOINT ; GENE-TRANSCRIPTION ; CANCER METABOLISM ; MAMMALIAN-CELLS ; TUMORIGENESIS ; BUB1 ; INSTABILITY ; PROMOTES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000329498600008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/57]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Jiang, Yuhui,Li, Xinjian,Yang, Weiwei,et al. PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells[J]. MOLECULAR CELL,2014,53(1):75-87. |
| APA | Jiang, Yuhui.,Li, Xinjian.,Yang, Weiwei.,Hawke, David H..,Zheng, Yanhua.,...&Lu, Zhimin.(2014).PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells.MOLECULAR CELL,53(1),75-87. |
| MLA | Jiang, Yuhui,et al."PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells".MOLECULAR CELL 53.1(2014):75-87. |
入库方式： OAI收割
来源：上海营养与健康研究所
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