PAQR3 Has Modulatory Roles in Obesity, Energy Metabolism, and Leptin Signaling
文献类型：期刊论文
| 作者 | Wang, Lingdi; Wang, Xiao; Li, Zhenghu; Xia, Tingting; Zhu, Lu; Liu, Bin; Zhang, Yongxian（张永贤）; Xiao, Fei; Pan, Yi（潘怡）; Liu, Yong（刘勇）
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| 刊名 | ENDOCRINOLOGY
 |
| 出版日期 | 2013 |
| 卷号 | 154期号:12页码:4525-4535 |
| 英文摘要 | Diet-induced obesity is commonly associated with leptin resistance, and attenuated leptin signaling contributes to the progression of obesity. PAQR3 is a member of the progesterone and AdipoQ receptor (PAQR) family with close homology to adiponectin receptors. We hypothesized that PAQR3 is implicated in the regulation of obesity and energy homeostasis. To address this hypothesis, we fed Paqr3-deleted mice with high-fat diet (HFD), followed by analyses to evaluate obesity, hepatic steatosis, insulin resistance, metabolic rate, and leptin signaling. We found that mice with deletion of Paqr3 are resistant to HFD-induced obesity and hepatic steatosis, accompanied by improvement of insulin resistance and insulin signaling. Paqr3-deleted mice have an increased energy expenditure and physical activity. HFD-induced leptin resistance is reversed by Paqr3 ablation. Overexpression of PAQR3 reduces leptin signaling whereas deletion of Paqr3 enhances leptin signaling in the hypothalamus. In conclusion, this study reveals that PAQR3 has an important physiological function in modulating obesity, energy metabolism, and leptin signaling. |
| 类目[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | CENTRAL-NERVOUS-SYSTEM ; DIET-INDUCED OBESITY ; GLUCOSE-HOMEOSTASIS ; GOLGI-APPARATUS ; BODY-WEIGHT ; ER STRESS ; RESISTANCE ; RKTG ; RECEPTOR ; BRAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000327545200010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/58]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 中国科学院上海生命科学研究院营养科学研究所_代谢的遗传与营养调控研究组 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Lingdi,Wang, Xiao,Li, Zhenghu,et al. PAQR3 Has Modulatory Roles in Obesity, Energy Metabolism, and Leptin Signaling[J]. ENDOCRINOLOGY,2013,154(12):4525-4535. |
| APA | Wang, Lingdi.,Wang, Xiao.,Li, Zhenghu.,Xia, Tingting.,Zhu, Lu.,...&Chen, Yan.(2013).PAQR3 Has Modulatory Roles in Obesity, Energy Metabolism, and Leptin Signaling.ENDOCRINOLOGY,154(12),4525-4535. |
| MLA | Wang, Lingdi,et al."PAQR3 Has Modulatory Roles in Obesity, Energy Metabolism, and Leptin Signaling".ENDOCRINOLOGY 154.12(2013):4525-4535. |
入库方式： OAI收割
来源：上海营养与健康研究所
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