Critical Roles of p53 in Epithelial-Mesenchymal Transition and Metastasis of Hepatocellular Carcinoma Cells
文献类型：期刊论文
| 作者 | Wang, Zheng; Jiang, Yuhui; Guan, Dongxian; Li, Jingjing; Yin, Hongkun; Pan, Yi（潘怡）; Xie, Dong（谢东）; Chen, Yan（陈雁）
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| 刊名 | PLOS ONE
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| 出版日期 | 2013 |
| 卷号 | 8期号:9页码:e72846 |
| 英文摘要 | Hepatocellular carcinoma (HCC) is one of the most malignant tumors and the biggest obstacle in curing HCC is its high metastasis potential. Alteration of p53 is the most frequent genetic change found in HCC. Although the biological function of p53 in tumor initiation and progression has been well characterized, whether or not p53 is implicated in metastasis of HCC is largely unknown. In this study, we analyzed the potential functions of p53 in epithelial-mesenchymal transition (EMT) and metastasis of HCC cells. Both insulin-and TGF-beta 1-induced changes of critical EMT markers were greatly enhanced by p53 knockdown in HCC cells. The insulin- and TGF-beta 1-stimulated migration of HCC cells were enhanced by p53 knockdown. Furthermore, in vivo metastasis of HCC cells using different mouse models was robustly enhanced by p53 knockdown. In addition, we found that p53 regulation on EMT and metastasis involves beta-catenin signaling. The nuclear accumulation and transcriptional activity of beta-catenin was modulated by p53. The enhanced EMT phenotype, cell migration and tumor metastasis of HCC cells by p53 knockdown were abrogated by inhibiting beta-catenin signal pathway. In conclusion, this study reveals that p53 plays a pivotal role in EMT and metastasis of HCC cells via its regulation on beta-catenin signaling. |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | CADHERIN GENE-EXPRESSION ; BREAST-CANCER CELLS ; BETA-CATENIN ; TUMOR PROGRESSION ; TGF-BETA ; MUTATION ; PROTEINS ; INHIBITION ; PATHWAY ; SNAIL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000324238400028 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/59]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 中国科学院上海生命科学研究院营养科学研究所_营养与肿瘤分子生物学研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Zheng,Jiang, Yuhui,Guan, Dongxian,et al. Critical Roles of p53 in Epithelial-Mesenchymal Transition and Metastasis of Hepatocellular Carcinoma Cells[J]. PLOS ONE,2013,8(9):e72846. |
| APA | Wang, Zheng.,Jiang, Yuhui.,Guan, Dongxian.,Li, Jingjing.,Yin, Hongkun.,...&Chen, Yan.(2013).Critical Roles of p53 in Epithelial-Mesenchymal Transition and Metastasis of Hepatocellular Carcinoma Cells.PLOS ONE,8(9),e72846. |
| MLA | Wang, Zheng,et al."Critical Roles of p53 in Epithelial-Mesenchymal Transition and Metastasis of Hepatocellular Carcinoma Cells".PLOS ONE 8.9(2013):e72846. |
入库方式： OAI收割
来源：上海营养与健康研究所
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