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Sma- and Mad-related Protein 7 (Smad7) Is Required for Embryonic Eye Development in the Mouse
文献类型：期刊论文
| 作者 | Zhang, Rui; Huang, Heng; Cao, Peijuan; Wang, ZhenZhen（王甄真）; Chen, Yan（陈雁） ; Pan, Yi（潘怡）
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| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
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| 出版日期 | 2013 |
| 卷号 | 288期号:15页码:10275-10285 |
| 英文摘要 | Smad7 is an intracellular inhibitory protein that antagonizes the signaling of TGF-beta family members. Deletion of Smad7 in the mouse leads to an abnormality in heart development. However, whether Smad7 has a functional role in the development of other organs has been elusive. Here we present evidence that Smad7 imparts a role to eye development in the mouse. Smad7 is expressed in both the lens and retina in the developing embryonic eye. Depletion of Smad7 caused various degrees of coloboma and microphthalmia with alterations in cell apoptosis and proliferation in eyes. Smad7 was implicated in lens differentiation but was not required for the induction of the lens placode. The development of the periocular mesenchyme was retarded with the down-regulation of Bmp7 and Pitx2 in mutant mice. Retinal spatial patterning was affected by Smad7 deletion and was accompanied by altered bone morphogenetic protein (BMP) signaling. At late gestation stages, TGF-beta signaling was up-regulated in the differentiating retina. Smad7 mutant mice displayed an expanded optic disc with increasing of sonic hedgehog (SHH) signaling. Furthermore, loss of Smad7 led to a temporal change in retinal neurogenesis. In conclusion, our study suggests that Smad7 is essential for eye development. In addition, our data indicate that alterations in the signaling of BMP, TGF-beta, and SHH likely underlie the defects in eye development caused by Smad7 deletion. |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | ANTERIOR SEGMENT DEVELOPMENT ; BONE MORPHOGENETIC PROTEINS ; NEURAL CREST ; TGF-BETA ; RETINAL DEVELOPMENT ; KNOCKOUT MICE ; OPTIC VESICLE ; GENE ; EXPRESSION ; OVEREXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000317565000009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/61]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Zhang, Rui,Huang, Heng,Cao, Peijuan,et al. Sma- and Mad-related Protein 7 (Smad7) Is Required for Embryonic Eye Development in the Mouse[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2013,288(15):10275-10285. |
| APA | Zhang, Rui,Huang, Heng,Cao, Peijuan,Wang, ZhenZhen,Chen, Yan,&Pan, Yi.(2013).Sma- and Mad-related Protein 7 (Smad7) Is Required for Embryonic Eye Development in the Mouse.JOURNAL OF BIOLOGICAL CHEMISTRY,288(15),10275-10285. |
| MLA | Zhang, Rui,et al."Sma- and Mad-related Protein 7 (Smad7) Is Required for Embryonic Eye Development in the Mouse".JOURNAL OF BIOLOGICAL CHEMISTRY 288.15(2013):10275-10285. |
入库方式： OAI收割
来源：上海营养与健康研究所
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