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PAQR3 Plays a Suppressive Role in the Tumorigenesis of Colorectal Cancers
文献类型：期刊论文
| 作者 | Wang, Xiao; Li, Xuebing; Fan, Fengjuan; Jiao, Shi; Wang, Lingdi; Zhu, Lu; Pan, Yi（潘怡）; Wu, Guohao; Ling, Zhi-Qiang; Fang, Jing（方靖） |
| 刊名 | CARCINOGENESIS
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:11页码:2228-2235 |
| 英文摘要 | PAQR3 is a member of the progestin and adipoQ receptor (PAQR) family and was recently characterized as a spatial regulator that negatively modulates Ras/Raf/MEK/ERK signaling cascade. However, little is known about the physiological functions of PAQR3 in the tumorigenesis of colorectal cancers. The function of PAQR3 in colorectal cancer development in mice was analyzed by crossing Paqr3-depleted mice with Apc(Min/+) mice that have a germline mutation of the gene-encoding tumor suppressor adenomatous polyposis coli (APC). The survival time and tumor area in the small intestine of the Apc(Min/+) mice was significantly aggravated by Paqr3 deletion. The cell proliferation rate, anchorage-independent growth, EGF-stimulated ERK phosphorylation and EGF-induced nuclear accumulation of beta-catenin were inhibited by PAQR3 overexpression and enhanced by PAQR3 knockdown in SW-480 colorectal cancer cells. In humans, the expression level of PAQR3 was significantly decreased in colorectal cancer samples in comparison with adjacent normal tissues. In addition, the expression level of PAQR3 was inversely associated with tumor grade in the colorectal cancer samples. Collectively, our data reveal for the first time that PAQR3 has a tumor suppressor activity in the development of colorectal cancers. |
| 类目[WOS] | Oncology |
| 关键词[WOS] | FAMILIAL ADENOMATOUS POLYPOSIS ; MULTIPLE INTESTINAL NEOPLASIA ; BETA-CATENIN ; RKTG ; MOUSE ; CELLS ; IDENTIFICATION ; PROLIFERATION ; MUTATIONS ; GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000310624400025 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/66]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 中国科学院上海生命科学研究院营养科学研究所_营养与癌症研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Xiao,Li, Xuebing,Fan, Fengjuan,et al. PAQR3 Plays a Suppressive Role in the Tumorigenesis of Colorectal Cancers[J]. CARCINOGENESIS,2012,33(11):2228-2235. |
| APA | Wang, Xiao.,Li, Xuebing.,Fan, Fengjuan.,Jiao, Shi.,Wang, Lingdi.,...&Chen, Yan.(2012).PAQR3 Plays a Suppressive Role in the Tumorigenesis of Colorectal Cancers.CARCINOGENESIS,33(11),2228-2235. |
| MLA | Wang, Xiao,et al."PAQR3 Plays a Suppressive Role in the Tumorigenesis of Colorectal Cancers".CARCINOGENESIS 33.11(2012):2228-2235. |
入库方式： OAI收割
来源：上海营养与健康研究所
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