Progesterone and AdipoQ Receptor 11 Links Ras Signaling to Cardiac Development in Zebrafish
文献类型：期刊论文
| 作者 | Huang, Heng; Jin, Ting; He, Jing; Ding, QiuRong（丁秋蓉） ; Xu, Daqian; Wang, Lingdi; Zhang, Yixuan; Pan, Yi（潘怡）; Wang, ZhenZhen（王甄真）; Chen, Yan（陈雁）
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| 刊名 | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
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| 出版日期 | 2012 |
| 卷号 | 32期号:9页码:2158 |
| 关键词 | heart development heart morphogenesis Ras subcellular organelle zebrafish |
| 英文摘要 | Objective-Progesterone and adipoQ receptor (PAQR) 10 and PAQR11 are 2 highly homologous genes involved in compartmentalized Ras signaling in the Golgi apparatus. The aim of this study was to investigate the physiological functions of PAQR10 and PAQR11. Methods and Results-We used zebrafish as a model system to analyze the potential function of PAQR10/PAQR11. The expression profiles of PAQR10 and PAQR11 in zebrafish embryos are overlapping in many areas, but only PAQR11 is expressed in the developing heart. Knockdown of PAQR11 but not PAQR10 in zebrafish embryos causes cardiac developmental defects, including dilation of cardiac chambers, abnormal heart looping, disruption of atrioventricular cushion formation, heart edema, and blood regurgitation. PAQR11 knockdown markedly reduces the number and proliferation rate of cardiomyocytes and alters the morphology of myocardial cells during early heart development. The cardiac defects caused by PAQR11 knockdown can be phenocopied by MEK inhibitors and a dominant negative Ras. Furthermore, constitutively active Ras and especially a Golgi-localized but not a plasma membrane-localized Ras are able to rescue the cardiac defects caused by PAQR11 knockdown. Conclusion-This study not only provides in vivo evidence that PAQR11 plays a critical role in heart morphogenesis but also pinpoints the importance of compartmentalized Ras signaling during development. (Arterioscler Thromb Vasc Biol. 2012; 32:2158-2170.) |
| 类目[WOS] | Hematology ; Peripheral Vascular Disease |
| 关键词[WOS] | FACIO-CUTANEOUS SYNDROME ; CAUSE NOONAN-SYNDROME ; HEART DEVELOPMENT ; GOLGI-APPARATUS ; VALVE FORMATION ; MORPHOGENESIS ; MUTATIONS ; RKTG ; PROLIFERATION ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000307773100018 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/67]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Huang, Heng,Jin, Ting,He, Jing,et al. Progesterone and AdipoQ Receptor 11 Links Ras Signaling to Cardiac Development in Zebrafish[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2012,32(9):2158. |
| APA | Huang, Heng.,Jin, Ting.,He, Jing.,Ding, QiuRong.,Xu, Daqian.,...&Chen, Yan.(2012).Progesterone and AdipoQ Receptor 11 Links Ras Signaling to Cardiac Development in Zebrafish.ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,32(9),2158. |
| MLA | Huang, Heng,et al."Progesterone and AdipoQ Receptor 11 Links Ras Signaling to Cardiac Development in Zebrafish".ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 32.9(2012):2158. |
入库方式： OAI收割
来源：上海营养与健康研究所
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