Associations of CFH Polymorphisms and CFHR1-CFHR3 Deletion with Blood Pressure and Hypertension in Chinese Population
文献类型：期刊论文
| 作者 | Gan, Wei; Wu, Johnna; Lu, Ling; Xiao, Xu; Huang, Heng; Wang, Fulong; Zhu, Jingwen; Sun, Liang（孙亮）; Liu, Gang; Pan, Yi（潘怡） |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:7页码:e42010 |
| 英文摘要 | Dysregulation of the complement system has been linked to pathogenesis of hypertension. However, whether genetic changes of complement factor H (CFH) and its related genes are associated with hypertension is unknown. We genotyped three SNPs in the CFH gene cluster that are closely linked to age-related macular degeneration, namely rs1061170 (Y402H), rs2274700 (A473A) and rs7542235 (CFHR1-3 Delta), and tested for their associations with blood pressure and hypertension risk in a population-based cohort including 3,210 unrelated Chinese Hans (50-70 years of age) from Beijing and Shanghai. We found that rs2274700 (A473A) and rs7542235 (CFHR1-3 Delta) were both significantly associated with diastolic blood pressure (DBP) (beta = 0.632-1.431, P <= 0.038) and systolic blood pressure (SBP) (beta = 1.567-4.445, P <= 0.008), and rs2274700 (A473A) was associated with hypertension risk (OR [95%CI]: 1.175 [1.005-1.373], P = 0.048). Notably, the associations of rs2274700 (A473A) with DBP (P = 2.1x10(-3)), SBP (P = 8x10(-5)) and hypertension risk (P = 7.9x10(-3)) were significant only in the individuals with low CRP levels (<2.0 mg/l), but not in those with CRP levels >= 2.0 mg/l (P >= 0.0807) (P for interaction <= 0.0467). However, no significant association between rs1061170 (Y402H) and blood pressure or hypertension risk was observed (P >= 0.259). In conclusion, our results suggest that genetic variations in CFH and its related genes may contribute to hypertension risk in Chinese Hans. |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | C-REACTIVE PROTEIN ; FACTOR-H POLYMORPHISM ; MACULAR DEGENERATION ; COMPLEMENT C3 ; MYOCARDIAL-INFARCTION ; SERUM C3 ; RISK ; VARIANT ; SUSCEPTIBILITY ; INFLAMMATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000306806600156 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/68]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Gan, Wei,Wu, Johnna,Lu, Ling,et al. Associations of CFH Polymorphisms and CFHR1-CFHR3 Deletion with Blood Pressure and Hypertension in Chinese Population[J]. PLOS ONE,2012,7(7):e42010. |
| APA | Gan, Wei.,Wu, Johnna.,Lu, Ling.,Xiao, Xu.,Huang, Heng.,...&Chen, Yan.(2012).Associations of CFH Polymorphisms and CFHR1-CFHR3 Deletion with Blood Pressure and Hypertension in Chinese Population.PLOS ONE,7(7),e42010. |
| MLA | Gan, Wei,et al."Associations of CFH Polymorphisms and CFHR1-CFHR3 Deletion with Blood Pressure and Hypertension in Chinese Population".PLOS ONE 7.7(2012):e42010. |
入库方式： OAI收割
来源：上海营养与健康研究所
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