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Dual-Mode Modulation of Smad Signaling by Smad-Interacting Protein Sip1 Is Required for Myelination in the Central Nervous System
文献类型：期刊论文
| 作者 | Weng, Qinjie; Chen, Ying; Wang, Haibo; Xu, Xiaomei; Yang, Bo; He, Qiaojun; Shou, Weinian; Chen, Yan（陈雁） ; Higashi, Yujiro; van den Berghe, Veronique
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| 刊名 | NEURON
 |
| 出版日期 | 2012 |
| 卷号 | 73期号:4页码:713-728 |
| 英文摘要 | Myelination by oligodendrocytes in the central nervous system (CNS) is essential for proper brain function, yet the molecular determinants that control this process remain poorly understood. The basic helix-loop-helix transcription factors Olig1 and Olig2 promote myelination, whereas bone morphogenetic protein (BMP) and Wnt/beta-catenin signaling inhibit myelination. Here we show that these opposing regulators of myelination are functionally linked by the Olig1/2 common target Smad-interacting protein-1 (Sip1). We demonstrate that Sip1 is an essential modulator of CNS myelination. Sip1 represses differentiation inhibitory signals by antagonizing BMP receptor-activated Smad activity while activating crucial oligodendrocyte-promoting factors. Importantly, a key Sip1-activated target, Smad7, is required for oligodendrocyte differentiation and partially rescues differentiation defects caused by Sip1 loss. Smad7 promotes myelination by blocking the BMP-and beta-catenin-negative regulatory pathways. Thus, our findings reveal that Sip1-mediated antagonism of inhibitory signaling is critical for promoting CNS myelination and point to new mediators for myelin repair. |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | BONE MORPHOGENETIC PROTEIN ; MOWAT-WILSON-SYNDROME ; OLIGODENDROCYTE PRECURSOR CELLS ; MULTIPLE-SCLEROSIS ; TRANSCRIPTION FACTORS ; BETA-CATENIN ; DEMYELINATED LESIONS ; CNS MYELINATION ; IN-VITRO ; DIFFERENTIATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000300815400011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/72]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Weng, Qinjie,Chen, Ying,Wang, Haibo,et al. Dual-Mode Modulation of Smad Signaling by Smad-Interacting Protein Sip1 Is Required for Myelination in the Central Nervous System[J]. NEURON,2012,73(4):713-728. |
| APA | Weng, Qinjie.,Chen, Ying.,Wang, Haibo.,Xu, Xiaomei.,Yang, Bo.,...&Lu, Q. Richard.(2012).Dual-Mode Modulation of Smad Signaling by Smad-Interacting Protein Sip1 Is Required for Myelination in the Central Nervous System.NEURON,73(4),713-728. |
| MLA | Weng, Qinjie,et al."Dual-Mode Modulation of Smad Signaling by Smad-Interacting Protein Sip1 Is Required for Myelination in the Central Nervous System".NEURON 73.4(2012):713-728. |
入库方式： OAI收割
来源：上海营养与健康研究所
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