High Fat Diet Induces Formation of Spontaneous Liposarcoma in Mouse Adipose Tissue with Overexpression of Interleukin 22
文献类型：期刊论文
| 作者 | Wang, Zheng; Yang, Ling; Jiang, Yuhui; Ling, Zhi-Qiang; Li, Zhigang; Cheng, Yuan; Huang, Heng ; Wang, Lingdi; Pan, Yi（潘怡）; Wang, Zhenzhen（王甄真）
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| 刊名 | PLOS ONE
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| 出版日期 | 2011 |
| 卷号 | 6期号:8页码:e23737 |
| 英文摘要 | Interleukin 22 (IL-22) is a T-cell secreted cytokine that modulates inflammatory response in nonhematopoietic tissues such as epithelium and liver. The function of IL-22 in adipose tissue is currently unknown. We generated a transgenic mouse model with overexpression of IL-22 specifically in adipose tissue. The IL-22 transgenic mice had no apparent changes in obesity and insulin resistance after feeding with high fat diet (HFD). Unexpectedly, all the IL-22 transgenic mice fed with HFD for four months developed spontaneous tumors in epididymal adipose tissue. Histological analysis indicated that the tumors were well-differentiated liposarcomas with infiltration of inflammatory cells. IL-22 overexpression promotes production of inflammatory cytokines such as IL-1 beta and IL-10 and stimulates ERK phosphorylation in adipose tissue. Furthermore, IL-22 treatment in differentiated 3T3-L1 adipocytes could induce IL-1 beta and IL-10 expression, together with stimulation of ERK phosphorylation. Taken together, our study not only established a novel mouse model with spontaneous liposarcoma, but also revealed that IL-22 overexpression may collaborate with diet-induced obesity to impact on tumor development in mouse. |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | MAP KINASE PATHWAYS ; INFLAMMATION ; IL-22 ; CANCER ; MODEL ; EXPRESSION ; INHIBITION ; CYTOKINE ; DISEASE ; IL-10 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000294676900018 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/74]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Wang, Zheng,Yang, Ling,Jiang, Yuhui,et al. High Fat Diet Induces Formation of Spontaneous Liposarcoma in Mouse Adipose Tissue with Overexpression of Interleukin 22[J]. PLOS ONE,2011,6(8):e23737. |
| APA | Wang, Zheng.,Yang, Ling.,Jiang, Yuhui.,Ling, Zhi-Qiang.,Li, Zhigang.,...&Chen, Yan.(2011).High Fat Diet Induces Formation of Spontaneous Liposarcoma in Mouse Adipose Tissue with Overexpression of Interleukin 22.PLOS ONE,6(8),e23737. |
| MLA | Wang, Zheng,et al."High Fat Diet Induces Formation of Spontaneous Liposarcoma in Mouse Adipose Tissue with Overexpression of Interleukin 22".PLOS ONE 6.8(2011):e23737. |
入库方式： OAI收割
来源：上海营养与健康研究所
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