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Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and rnitochondrial dysfunction: Regulatory effects of hydroxytyrosol
文献类型：期刊论文
| 作者 | Feng, Zhihui; Bai, Liyuan; Yan, Jiong; Li, Yuan; Shen, Weili; Wang, Ying; Wertz, Karin; Weber, Peter; Zhang, Yong; Chen, Yan（陈雁）
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| 刊名 | FREE RADICAL BIOLOGY AND MEDICINE
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| 出版日期 | 2011 |
| 卷号 | 50期号:10页码:1437-1446 |
| 关键词 | Mitochondrial biogenesis Autophagy Oxidative stress Apoptosis JNK pathway Erk1/2 pathway Free radicals |
| 英文摘要 | Physical exercise is considered to exert a positive effect on health, whereas strenuous or excessive exercise (Exe) causes fatigue and damage to muscle and immune functions. The underlying molecular mechanisms are still unclear. We designed a protocol to mimic Exe and explore the ensuing cellular damage and involvement of mitochondrial dynamics. We found that Exe was prone to decrease endurance capacity and induce damage to renal function and the immune system. Muscle atrophy markers atrogin-1 and MuRF1 mRNA were increased by Exe, accompanied by increased autophagy and mitochondrial fission in skeletal muscle. Exe caused a decrease in PGC-1 alpha and complex I expression; it also activated JNK and Erk1/2 pathways and consequently induced p53, p21, and MnSOD expression in skeletal muscle. The involvement of oxidant-induced autophagy and mitochondrial dysfunction was confirmed in C2C12 myoblasts. Hydroxytyrosol (HT), a natural olive polyphenol, efficiently enhanced endurance capacity and prevented Exe-induced renal and immune system darnage. Also, HT treatment inhibited both the Exe-induced increase in autophagy and mitochondrial fission and the decrease in PGC-1 alpha expression. In addition, HT enhanced mitochondrial fusion and mitochondrial complex I and II activities in muscle of Exe rats. These results demonstrate that Exe-induced fatigue and damage to muscle and immune functions may be mediated via the regulation of mitochondrial dynamic remodeling, including the downregulation of mitochondrial biogenesis and upregulation of autophagy. HT supplementation may regulate mitochondrial dynamic remodeling and enhance antioxidant defenses and thus improve exercise capacity under Exe conditions. (C) 2011 Elsevier Inc. All rights reserved. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 关键词[WOS] | MANGANESE SUPEROXIDE-DISMUTASE ; PIGMENT EPITHELIAL-CELLS ; INDUCED OXIDATIVE STRESS ; RAT-LIVER MITOCHONDRIA ; SKELETAL-MUSCLE ; SOLEUS MUSCLE ; OLIVE OIL ; RESPIRATORY-FUNCTION ; ANTIOXIDANT ACTIVITY ; PROTEIN-DEGRADATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000290694900025 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/75]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Feng, Zhihui,Bai, Liyuan,Yan, Jiong,et al. Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and rnitochondrial dysfunction: Regulatory effects of hydroxytyrosol[J]. FREE RADICAL BIOLOGY AND MEDICINE,2011,50(10):1437-1446. |
| APA | Feng, Zhihui.,Bai, Liyuan.,Yan, Jiong.,Li, Yuan.,Shen, Weili.,...&Liu, Jiankang.(2011).Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and rnitochondrial dysfunction: Regulatory effects of hydroxytyrosol.FREE RADICAL BIOLOGY AND MEDICINE,50(10),1437-1446. |
| MLA | Feng, Zhihui,et al."Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and rnitochondrial dysfunction: Regulatory effects of hydroxytyrosol".FREE RADICAL BIOLOGY AND MEDICINE 50.10(2011):1437-1446. |
入库方式： OAI收割
来源：上海营养与健康研究所
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