Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis
文献类型：期刊论文
| 作者 | Luo, Xiaolin; Zhang, Yongxian（张永贤）; Ruan, Xiangbo; Jiang, Xiaomeng; Zhu, Lu; Wang, Xiao; Ding, QiuRong（丁秋蓉） ; Liu, Weizhong; Pan, Yi（潘怡）; Wang, ZhenZhen（王甄真）
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| 刊名 | DIABETES
 |
| 出版日期 | 2011 |
| 卷号 | 60期号:5页码:1435-1445 |
| 英文摘要 | OBJECTIVE-Most animals experience fasting-feeding cycles throughout their lives. It is well known that the liver plays a central role in regulating glycogen metabolism. However, how hepatic glycogenesis is coordinated with the fasting-feeding cycle to control postprandial glucose homeostasis remains largely unknown. This study detemines the molecular mechanism underlying the coupling of hepatic glycogenesis with the fasting-feeding cycle. RESEARCH DESIGN AND METHODS-Through a series of molecular, cellular, and animal studies, we investigated how PPP1R3G, a glycogen-targeting regulatory subunit of protein phosphatase 1 (PP1), is implicated in regulating hepatic glycogenesis and glucose homeostasis in a manner tightly orchestrated with the fasting-feeding cycle. RESULTS-PPP1R3G in the liver is upregulated during fasting and downregulated after feeding. PPP1R3G associates with glycogen pellet, interacts with the catalytic subunit of PP1, and regulates glycogen synthase (GS) activity. Fasting glucose level is reduced when PPP1R3G is overexpressed in the liver. Hepatic knockdown of PPP1R3G reduces postprandial elevation of GS activity, decreases postprandial accumulation of liver glycogen, and decelerates postprandial clearance of blood glucose. Other glycogen-targeting regulatory subunits of PP1, such as PPP1R3B, PPP1R3C, and PPP1R3D, are downregulated by fasting and increased by feeding in the liver. CONCLUSIONS-We propose that the opposite expression pattern of PPP1R3G versus other PP1 regulatory subunits comprise an intricate regulatory machinery to control hepatic glycogenesis during the fasting-feeding cycle. Because of its unique expression pattern, PPP1R3G plays a major role to control postprandial glucose homeostasis during the fasting-feeding transition via its regulation on liver glycogenesis. Diabetes 60:1435-1445, 2011 |
| 类目[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | LIVER IN-VIVO ; TARGETING SUBUNIT ; SYNTHASE PHOSPHATASE ; INSULIN-RESISTANCE ; PHOSPHORYLASE-A ; DIABETIC RATS ; METABOLISM ; MUSCLE ; PTG ; GLUCOKINASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000290349700009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/76]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Luo, Xiaolin,Zhang, Yongxian,Ruan, Xiangbo,et al. Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis[J]. DIABETES,2011,60(5):1435-1445. |
| APA | Luo, Xiaolin.,Zhang, Yongxian.,Ruan, Xiangbo.,Jiang, Xiaomeng.,Zhu, Lu.,...&Chen, Yan.(2011).Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis.DIABETES,60(5),1435-1445. |
| MLA | Luo, Xiaolin,et al."Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis".DIABETES 60.5(2011):1435-1445. |
入库方式： OAI收割
来源：上海营养与健康研究所
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