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Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and up-regulation of UCP1 in brown fat
文献类型：期刊论文
| 作者 | Ruan, Xiangbo; Li, Zhenghu; Zhang, Yixuan; Yang, Ling; Pan, Yi（潘怡）; Wang, ZhenZhen（王甄真）; Feng, Gen-Sheng; Chen, Yan（陈雁）
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| 刊名 | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
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| 出版日期 | 2011 |
| 卷号 | 15期号:4页码:763-772 |
| 关键词 | obesity apolipoprotein A-I (ApoA-I) brown fat energy expenditure |
| 英文摘要 | Apolipoprotein A-I (ApoA-I) is the most abundant protein constituent of high-density lipoprotein (HDL). Reduced plasma HDL and ApoA-I levels have been found to be associated with obesity and metabolic syndrome in human beings. However, whether or not ApoA-I has a direct effect on obesity is largely unknown. Here we analysed the anti-obesity effect of ApoA-I using two mouse models, a transgenic mouse with overexpression of ApoA-I and the mice administered with an ApoA-I mimetic peptide D-4F. The mice were induced to develop obesity by feeding with high fat diet. Both ApoA-I overexpression and D-4F treatment could significantly reduce white fat mass and slightly improve insulin sensitivity in the mice. Metabolic analyses revealed that ApoA-I overexpression and D-4F treatment enhanced energy expenditure in the mice. The mRNA level of uncoupling protein (UCP)1 in brown fat tissue was elevated by ApoA-I transgenic mice. ApoA-I and D-4F treatment was able to increase UCP1 mRNA and protein levels as well as to stimulate AMP-activated protein kinase (AMPK) phosphorylation in brown adipocytes in culture. Taken together, our results reveal that ApoA-I has an anti-obesity effect in the mouse and such effect is associated with increases in energy expenditure and UCP1 expression in the brown fat tissue. |
| 类目[WOS] | Cell Biology ; Medicine, Research & Experimental |
| 关键词[WOS] | HIGH-DENSITY-LIPOPROTEIN ; MECHANISMS LINKING OBESITY ; MIMETIC PEPTIDE ; CARDIOVASCULAR-DISEASE ; INSULIN-RESISTANCE ; ADIPOSE-TISSUE ; METABOLIC-SYNDROME ; MICE ; PLASMA ; D-4F |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000290312700006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/78]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Ruan, Xiangbo,Li, Zhenghu,Zhang, Yixuan,et al. Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and up-regulation of UCP1 in brown fat[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2011,15(4):763-772. |
| APA | Ruan, Xiangbo.,Li, Zhenghu.,Zhang, Yixuan.,Yang, Ling.,Pan, Yi.,...&Chen, Yan.(2011).Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and up-regulation of UCP1 in brown fat.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,15(4),763-772. |
| MLA | Ruan, Xiangbo,et al."Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and up-regulation of UCP1 in brown fat".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 15.4(2011):763-772. |
入库方式： OAI收割
来源：上海营养与健康研究所
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