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A Marker of Endotoxemia Is Associated With Obesity and Related Metabolic Disorders in Apparently Healthy Chinese
文献类型：期刊论文
| 作者 | Sun, Liang（孙亮）; Yu, Zhijie; Ye, Xingwang; Zou, Shurong; Li, Huaixing（黎怀星）; Yu, Danxia; Wu, Hongyu; Chen, Yan（陈雁） ; Dore, Joel; Clement, Karine
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| 刊名 | DIABETES CARE
 |
| 出版日期 | 2010 |
| 卷号 | 33期号:9页码:1925-1932 |
| 英文摘要 | OBJECTIVE - Elevated lipopolysaccharide-binding protein (LBP), a marker of subclinical endotoxemia, may be involved in the pathogenesis of obesity and metabolic risk. We aimed to investigate the association between plasma LBP and metabolic disorders in apparently healthy Chinese. RESEARCH DESIGN AND METHODS - A population-based study including 559 overweight/obese (BMI >= 24.0 kg/m(2)) and 500 normal-weight (18.0 <= BMI < 24.0 kg/m(2)) subjects aged 35-54 years was conducted in Shanghai, China. Fasting plasma glucose, lipid profile, LBP, high-sensitivity C-reactive protein, interleukin-6, high-molecular-weight (HMW) adiponectin, leptin, hepatic enzymes, and body composition were measured. Metabolic syndrome was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criterion for Asian Americans. RESULTS - LBP levels were significantly higher in overweight/obese individuals than in normal-weight individuals (geometric mean 27.6 [95% CI 25.2-30.3] vs. 10.0 [9.1-11.1] mu g/ml; P < 0.001). After multiple adjustments including BMI, the odds ratios were 3.54 (95% CI 2.05-6.09) and 5.53 (95% CI 2.64-11.59) for metabolic syndrome and type 2 diabetes, respectively, comparing the highest with the lowest LBP quartile. Further adjustments for inflammatory markers almost abolished the significant association of LBP with metabolic syndrome but not that with type 2 diabetes, and controlling for adipokines and hepatic enzymes did not substantially alter the results. CONCLUSIONS - Elevated circulating LBP was associated with obesity, metabolic syndrome, and type 2 diabetes in apparently healthy Chinese. These findings suggested a role of lipopolysaccharide via initiation of innate immune mechanism(s) in metabolic disorders. Prospective studies are needed to confirm these results. |
| 类目[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | BACTERICIDAL/PERMEABILITY-INCREASING PROTEIN ; BINDING PROTEIN ; INFLAMMATION ; DISEASE ; GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000282560300003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/80]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 中国科学院上海生命科学研究院营养科学研究所_人类营养与疾病研究组 |
| 推荐引用方式 GB/T 7714 | Sun, Liang,Yu, Zhijie,Ye, Xingwang,et al. A Marker of Endotoxemia Is Associated With Obesity and Related Metabolic Disorders in Apparently Healthy Chinese[J]. DIABETES CARE,2010,33(9):1925-1932. |
| APA | Sun, Liang.,Yu, Zhijie.,Ye, Xingwang.,Zou, Shurong.,Li, Huaixing.,...&Lin, Xu.(2010).A Marker of Endotoxemia Is Associated With Obesity and Related Metabolic Disorders in Apparently Healthy Chinese.DIABETES CARE,33(9),1925-1932. |
| MLA | Sun, Liang,et al."A Marker of Endotoxemia Is Associated With Obesity and Related Metabolic Disorders in Apparently Healthy Chinese".DIABETES CARE 33.9(2010):1925-1932. |
入库方式： OAI收割
来源：上海营养与健康研究所
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