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Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22
文献类型：期刊论文
| 作者 | Yang, Ling; Zhang, Yixuan; Wang, Lingdi; Fan, Fengjuan; Zhu, Lu; Li, Zhigang; Ruan, Xiangbo; Huang, Heng; Wang, ZhenZhen（王甄真）; Huang, Zhihua |
| 刊名 | JOURNAL OF HEPATOLOGY
 |
| 出版日期 | 2010 |
| 卷号 | 53期号:2页码:339-347 |
| 关键词 | IL-22 Fatty liver Lipid metabolism Mouse model IL-22R1 STAT3 |
| 英文摘要 | Background & Aims: Interleukin-22 (IL-22) is a Th17-related cytokine within the IL-10 family and plays an important role in host defense and inflammatory responses in orchestration with other Th17 cytokines. IL-22 exerts its functions in non-immune cells as its functional receptor IL-22R1 is restricted in peripheral tissues but not in immune cells. It was recently found that IL-22 serves as a protective molecule to counteract the destructive nature of the T cell-mediated immune response to liver damage. However, it is currently unknown whether IL-22 has an effect on lipid metabolism in the liver. Methods: In this study, we demonstrate that IL-22 alleviates hepatic steatosis induced by high fat diet (HFD). Results: Administration of recombinant murine IL-22 (rmIL-22) was able to stimulate STAT3 phosphorylation in HepG2 cells and mouse liver. The activation of STAT3 by rmIL-22 was reduced by the over-expression of a dominant negative IL-22R1. Within hours after rmIL-22 treatment, the expression of lipogenesis-related genes including critical transcription factors and enzymes for lipid synthesis in the liver was significantly down-regulated. The levels of triglyceride and cholesterol in the liver were significantly reduced by long-term treatment of rmIL-22 in C57BL/6 and ob/ob mice fed with HFD. The HFD-induced increases of ALT and AST in ob/ob mice were ameliorated by rmIL-22 treatment. In addition, the expression of fatty acid synthase and TNF-alpha in the liver was decreased by long-term rmIL-22 administration. Conclusions: Collectively, these data indicate that IL-22, in addition to its known functions in host defense and inflammation, has a protective role in HFD-induced hepatic steatosis via its regulation on lipid metabolism in the liver. (C) 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
| 类目[WOS] | Gastroenterology & Hepatology |
| 关键词[WOS] | INDUCED INSULIN-RESISTANCE ; T-CELL ; SKIN INFLAMMATION ; GENE-EXPRESSION ; DEFICIENT MICE ; HOST-DEFENSE ; OB/OB MICE ; IL-22 ; CYTOKINE ; RECEPTOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000280470900020 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/81]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Yang, Ling,Zhang, Yixuan,Wang, Lingdi,et al. Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22[J]. JOURNAL OF HEPATOLOGY,2010,53(2):339-347. |
| APA | Yang, Ling.,Zhang, Yixuan.,Wang, Lingdi.,Fan, Fengjuan.,Zhu, Lu.,...&Chen, Yan.(2010).Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22.JOURNAL OF HEPATOLOGY,53(2),339-347. |
| MLA | Yang, Ling,et al."Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22".JOURNAL OF HEPATOLOGY 53.2(2010):339-347. |
入库方式： OAI收割
来源：上海营养与健康研究所
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