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Smad7 Is Required for the Development and Function of the Heart
文献类型：期刊论文
| 作者 | Chen, Qian; Chen, Hanying; Zheng, Dawei; Kuang, Chenzhong; Fang, Hong; Zou, Bingyu; Zhu, Wuqiang; Bu, Guixue; Jin, Ting; Wang, ZhenZhen（王甄真） |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2009 |
| 卷号 | 284期号:1页码:292-300 |
| 英文摘要 | Transforming growth factor-beta (TGF-beta) family members, including TGF-beta s, activins, and bone morphogenetic proteins, exert diverse biological activities in cell proliferation, differentiation, apoptosis, embryonic development, and many other processes. These effects are largely mediated by Smad proteins. Smad7 is a negative regulator for the signaling of TGF-beta family members. Dysregulation of Smad7 is associated with pathogenesis of a variety of human diseases. However, the in vivo physiological roles of Smad7 have not been elucidated due to the lack of a mouse model with significant loss of Smad7 function. Here we report generation and initial characterization of Smad7 mutant mice with targeted deletion of the indispensable MH2 domain. The majority of Smad7 mutant mice died in utero due to multiple defects in cardiovascular development, including ventricular septal defect and non-compaction, as well as outflow tract malformation. The surviving adult Smad7 mutant mice had impaired cardiac functions and severe arrhythmia. Further analyses suggest that Smad2/3 phosphorylation was elevated in atrioventricular cushion in the heart of Smad7 mutant mice, accompanied by increased apoptosis in this region. Taken together, these observations pinpoint an important role of Smad7 in the development and function of the mouse heart in vivo. |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | EARLY MOUSE EMBRYO ; TGF-BETA ; CARDIAC DEVELOPMENT ; ENDOCARDIAL CUSHION ; NEUREGULIN RECEPTOR ; MESODERM INDUCTION ; COLORECTAL-CANCER ; CELL-MEMBRANE ; MICE LACKING ; EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000261974800033 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/90]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Chen, Qian,Chen, Hanying,Zheng, Dawei,et al. Smad7 Is Required for the Development and Function of the Heart[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2009,284(1):292-300. |
| APA | Chen, Qian.,Chen, Hanying.,Zheng, Dawei.,Kuang, Chenzhong.,Fang, Hong.,...&Chen, Yan.(2009).Smad7 Is Required for the Development and Function of the Heart.JOURNAL OF BIOLOGICAL CHEMISTRY,284(1),292-300. |
| MLA | Chen, Qian,et al."Smad7 Is Required for the Development and Function of the Heart".JOURNAL OF BIOLOGICAL CHEMISTRY 284.1(2009):292-300. |
入库方式： OAI收割
来源：上海营养与健康研究所
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