Protection of cerulein-induced pancreatic fibrosis by pancreas-specific expression of Smad7
文献类型：期刊论文
| 作者 | He, Jing; Sun, Xiaolan; Qian, Ke-Qing; Liu, Xubao; Wang, ZhenZhen（王甄真）; Chen, Yan（陈雁）
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| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
 |
| 出版日期 | 2009 |
| 卷号 | 1792期号:1页码:56-60 |
| 关键词 | Chronic pancreatitis Fibrosis Smad7 TGF-beta Transgenic mouse |
| 英文摘要 | Pancreatic fibrosis is the hallmark of chronic pancreatitis, currently an incurable disease. Pancreatitis fibrosis is caused by deposition of extracellular matrix (ECM) and the underlying pathological mechanism remains unclear. In addition to its broad biological activities, TGF-beta is a potent pro-fibrotic factor and many in vitro studies using cell systems have implicated a functional role of TGF-beta in the pathogenesis of pancreatic fibrosis. We analyzed the in vivo role of TGF-beta pathway in pancreatic fibrosis in this study. Smad7, an intracellular inhibitory protein that antagonizes TGF-beta signaling, was specifically expressed in the pancreas using a transgenic mouse model. Chronic pancreatitis was induced in the mouse with repeated administration of cerulein. Smad7 expression in the pancreas was able to significantly inhibit cerulein-induced pancreatic fibrosis. Consistently, the protein levels of collagen 1 and fibronectin were decreased in the Smad7 transgenic mice. In addition, alpha-smooth muscle actin, a marker of activated pancreas stellate cells, was reduced in the transgenic mice. Taken together, these data indicate that inhibition of TGF-beta signaling by Smad7 is able to protect cerulein-induced pancreatic fibrosis in vivo. (C) 2008 Elsevier B.V. All rights reserved. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | GROWTH-FACTOR-BETA ; STELLATE CELLS ; TRANSFORMING GROWTH-FACTOR-BETA-1 ; EXTRACELLULAR-MATRIX ; IN-VIVO ; RAT ; IDENTIFICATION ; PROLIFERATION ; FIBROGENESIS ; INHIBITION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000262547900007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/91]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | He, Jing,Sun, Xiaolan,Qian, Ke-Qing,et al. Protection of cerulein-induced pancreatic fibrosis by pancreas-specific expression of Smad7[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,2009,1792(1):56-60. |
| APA | He, Jing,Sun, Xiaolan,Qian, Ke-Qing,Liu, Xubao,Wang, ZhenZhen,&Chen, Yan.(2009).Protection of cerulein-induced pancreatic fibrosis by pancreas-specific expression of Smad7.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1792(1),56-60. |
| MLA | He, Jing,et al."Protection of cerulein-induced pancreatic fibrosis by pancreas-specific expression of Smad7".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1792.1(2009):56-60. |
入库方式： OAI收割
来源：上海营养与健康研究所
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