Negative regulation of adiponectin receptor 1 promoter by insulin via a repressive nuclear inhibitory protein element
文献类型：期刊论文
| 作者 | Sun, Xiaolan; He, Jing; Mao, Chenqian; Han, Ruijun; Wang, ZhenZhen（王甄真）; Liu, Yong（刘勇） ; Chen, Yan（陈雁）
|
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2008 |
| 卷号 | 582期号:23-24页码:3401-3407 |
| 关键词 | Adiponectin receptor Insulin Nuclear inhibitory protein element Foxo1 |
| 英文摘要 | Adiponectin is an adipose-derived hormone that has anti-diabetic and anti-atherogenic effects through interaction with adiponectin receptors AdipoR1 and AdipoR2. We analyzed the transcriptional regulation of AdipoR1 by insulin. Insulin repressed the promoter activity of AdipoR1 in C2C12 myoblasts via PI3K and Foxo1. Deletion studies demonstrated the presence of a putative insulin-responsive region which is composed of a nuclear inhibitory protein (NIP) binding element. Mutation of the NIP element abrogated the negative regulation of AdipoR1 promoter by insulin. Insulin treatment could induce formation of a protein complex that bound the NIP element. Collectively, our data suggest that a repressive NIP element is involved in the negative regulation of AdipoR1 promoter by insulin. |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | FORKHEAD TRANSCRIPTION FACTOR ; GENE-EXPRESSION ; LIPID-METABOLISM ; KINASE B ; SENSITIVITY ; GLUCOSE ; ADIPOSE ; PLASMA ; FKHR ; AKT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000260806700026 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/92]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 中国科学院上海生命科学研究院营养科学研究所_糖脂代谢与调控研究组 |
| 推荐引用方式 GB/T 7714 | Sun, Xiaolan,He, Jing,Mao, Chenqian,et al. Negative regulation of adiponectin receptor 1 promoter by insulin via a repressive nuclear inhibitory protein element[J]. FEBS LETTERS,2008,582(23-24):3401-3407. |
| APA | Sun, Xiaolan.,He, Jing.,Mao, Chenqian.,Han, Ruijun.,Wang, ZhenZhen.,...&Chen, Yan.(2008).Negative regulation of adiponectin receptor 1 promoter by insulin via a repressive nuclear inhibitory protein element.FEBS LETTERS,582(23-24),3401-3407. |
| MLA | Sun, Xiaolan,et al."Negative regulation of adiponectin receptor 1 promoter by insulin via a repressive nuclear inhibitory protein element".FEBS LETTERS 582.23-24(2008):3401-3407. |
入库方式： OAI收割
来源：上海营养与健康研究所
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