Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse
文献类型：期刊论文
| 作者 | Xie, Xiaoduo; Zhang, Yixuan; Jiang, Yuhui; Liu, Weizhong; Ma, Hong; Wang, ZhenZhen（王甄真）; Chen, Yan（陈雁）
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| 刊名 | CARCINOGENESIS
 |
| 出版日期 | 2008 |
| 卷号 | 29期号:8页码:1632-1638 |
| 英文摘要 | Raf kinase trapping to Golgi (RKTG) is a newly characterized negative regulator of the Ras-Raf-MEK-ERK signaling pathway via sequestrating Raf-1 to the Golgi apparatus. However, little is known about the physiological functions of RKTG in mitogenic pathway and carcinogenesis. Here, we describe a suppressive role of RKTG in skin carcinogenesis by analyzing chemical carcinogen-induced tumorigenesis. Epidermis hyperplasia and proliferation are increased in RKTG-deficient mice (RKTG(-/-)) after acute treatment with 7, 12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA). Using a two-stage DMBA/TPA carcinogenesis protocol on mouse skin, the number and size of papillomas are increased in RKTG(-/)mice, accompanied by shortened tumor latency and enhanced keratinocyte proliferation. The regression of the carcinogen-induced tumors is also prolonged in RKTG(-/-) mice. Consistently, the levels of Raf-1 and extracellular signal-regulated kinase phosphorylation in primary keratinocytes as well as skin tumors are elevated when RKTG is disrupted. Collectively, our results indicate that RKTG has a suppressive activity in chemical carcinogen-induced mitogenesis and tumor formation in mouse skin. |
| 类目[WOS] | Oncology |
| 关键词[WOS] | RAS ; CANCER ; LOCALIZATION ; ACTIVATION ; GOLGI ; CELLS ; MODEL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000258471900022 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/93]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Xie, Xiaoduo,Zhang, Yixuan,Jiang, Yuhui,et al. Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse[J]. CARCINOGENESIS,2008,29(8):1632-1638. |
| APA | Xie, Xiaoduo.,Zhang, Yixuan.,Jiang, Yuhui.,Liu, Weizhong.,Ma, Hong.,...&Chen, Yan.(2008).Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse.CARCINOGENESIS,29(8),1632-1638. |
| MLA | Xie, Xiaoduo,et al."Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse".CARCINOGENESIS 29.8(2008):1632-1638. |
入库方式： OAI收割
来源：上海营养与健康研究所
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