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Spatial regulation of Raf kinase signaling by RKTG
文献类型：期刊论文
| 作者 | Feng, Lin; Xie, Xiaoduo; Ding, QiuRong（丁秋蓉） ; Luo, Xiaolin; He, Jing; Fan, Fengjuan; Liu, Weizhong; Wang, ZhenZhen（王甄真）; Chen, Yan（陈雁）
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| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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| 出版日期 | 2007 |
| 卷号 | 104期号:36页码:14348-14353 |
| 关键词 | EGF ERK Golgi Raf-1 Ras PAQR3 |
| 英文摘要 | Subcellular compartmentalization has become an important theme in cell signaling such as spatial regulation of Ras by RasGRP1 and MEK/ERK by Sef. Here, we report spatial regulation of Raf kinase by RKTG (Raf kinase trapping to Golgi). RKTG is a seven-transmembrane protein localized at the Golgi apparatus. RKTG expression inhibits EGF-stimulated ERK and RSK phosphorylation, blocks NGF-mediated PC12 cell differentiation, and antagonizes Ras- and Raf-1 -stimulated Elk-1 transactivation. Through interaction with Raf-1, RKTG changes the localization of Raf-1 from cytoplasm to the Golgi apparatus, blocks EGF-stimulated Raf-1 membrane translocation, and reduces the interaction of Raf-1 with Ras and MEK1. In RKTG-null mice, the basal ERK phosphorylation level is increased in the brain and liver. In RKTG-deleted mouse embryonic fibroblasts, EGF-induced ERK phosphorylation is enhanced. Collectively, our results reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway. |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | EPIDERMAL-GROWTH-FACTOR ; ADIPONECTIN RECEPTORS ; PROTEIN-KINASE ; ACTIVATION ; MEMBRANE ; PHOSPHORYLATION ; CELLS ; LOCALIZATION ; GOLGI ; SPECIFICITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000249333600032 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/96]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Feng, Lin,Xie, Xiaoduo,Ding, QiuRong,et al. Spatial regulation of Raf kinase signaling by RKTG[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2007,104(36):14348-14353. |
| APA | Feng, Lin.,Xie, Xiaoduo.,Ding, QiuRong.,Luo, Xiaolin.,He, Jing.,...&Chen, Yan.(2007).Spatial regulation of Raf kinase signaling by RKTG.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,104(36),14348-14353. |
| MLA | Feng, Lin,et al."Spatial regulation of Raf kinase signaling by RKTG".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104.36(2007):14348-14353. |
入库方式： OAI收割
来源：上海营养与健康研究所
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