Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction
文献类型：期刊论文
| 作者 | Xie, Xiaoduo; Wang, Zhenzhen（王甄真）; Chen, Yan（陈雁）
|
| 刊名 | MOLECULAR AND CELLULAR BIOCHEMISTRY
 |
| 出版日期 | 2007 |
| 卷号 | 301期号:2015-01-02页码:115-122 |
| 关键词 | LKB1 WDR6 cell cycle tumor suppressor p27(Kip1) Peutz-Jeghers syndrome WD-repeat |
| 英文摘要 | Germline mutations of the serine/threonine kinase LKB1 (also known as STK11) lead to Peutz-Jeghers syndrome (PJS) that is associated with increased incidence of malignant cancers. However, the tumor suppressor function of LKB1 has not been fully elucidated. We applied yeast two-hybrid screening and identified that a novel WD-repeat protein WDR6 was able to interact with LKB1. Immunofluorescence staining revealed that WDR6 was localized in cytoplasm, similar to the localization of LKB1. Expression of LKB1 was able to inhibit colony formation of Hela cells. Interestingly, coexpression of WDR6 with LKB1 enhanced the inhibitory effect of LKB1 on Hela cell proliferation. Consistently, WDR6 was able to synergize with LKB1 in cell cycle G1 arrest in Hela cells. Coexpression of WDR6 and LKB1 was able to induce p27(Kip1) a cyclin-dependent kinase (CDK) inhibitor Furthermore, the stimulatory effect of LKB1 on p27Kip1 promoter activity was significantly elevated by coexpression with WDR6. Collectively, these results provided initial evidence that WDR6 is implicated in the cell growth inhibitory pathway of LKB1 via regulations p27(Kip1). |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | PEUTZ-JEGHERS-SYNDROME ; TUMOR-SUPPRESSOR ; KINASE ; GENE ; DEREGULATION ; EXPRESSION ; CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000247679400011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/97]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Xie, Xiaoduo,Wang, Zhenzhen,Chen, Yan. Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2007,301(2015-01-02):115-122. |
| APA | Xie, Xiaoduo,Wang, Zhenzhen,&Chen, Yan.(2007).Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction.MOLECULAR AND CELLULAR BIOCHEMISTRY,301(2015-01-02),115-122. |
| MLA | Xie, Xiaoduo,et al."Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction".MOLECULAR AND CELLULAR BIOCHEMISTRY 301.2015-01-02(2007):115-122. |
入库方式： OAI收割
来源：上海营养与健康研究所
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