Catalase potentiates retinoic acid-induced THP-1 monocyte differentiation into macrophage through inhibition of peroxisome proliferator-activated receptor gamma
文献类型：期刊论文
| 作者 | Ding, Qiurong（丁秋蓉） ; Jin, Ting; Wang, Zhenzhen（王甄真）; Chen, Yan（陈雁）
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| 刊名 | JOURNAL OF LEUKOCYTE BIOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 81期号:6页码:1568-1576 |
| 关键词 | PPAR ROS ATRA hydrogen peroxide |
| 英文摘要 | Macrophage differentiation plays a pivotal role in cardiovascular diseases and many other physiological processes. However, the role of reaction oxygen species in macrophage differentiation has not been elucidated. Here, we report functional characterization of catalase, an enzyme that degrades hydrogen peroxide (H2O2)1 in THP-1 monocyte differentiation. Treatment of THP-1 cells with catalase was able to synergize with all-trans retinoic acid (ATRA) to enhance macrophage differentiation, demonstrated by changes of cell adherence, cell cycle arrest, nitroblue tetrazolium reduction, and expression of differentiation markers including CD68, CD11b, and matrix metallo-proteinase 9 (MMP9). ATRA could stimulate retinoic acid (RA) receptor-mediated transcription, but this was not affected by catalase. However, ATRA and catalase were capable of reducing transcriptional activity mediated by peroxisome protiferator-activated receptor gamma (PPART). Consistently, PPART antagonists enhanced, and PPAR gamma agonists inhibited MMP9 expression stimulated by ATRA and catalase in THP-1 cells. Therefore, these data indicate that catalase is able to potentiate ATRA-induced macrophage differentiation by inhibition of PPART activity, underscoring an important interplay between H2O2, RA, and PPAR gamma in macrophages. |
| 类目[WOS] | Cell Biology ; Hematology ; Immunology |
| 关键词[WOS] | LEUKEMIA-CELL LINE ; PPAR-GAMMA ; OXIDATIVE STRESS ; SIGNAL-TRANSDUCTION ; GROWTH-INHIBITION ; LIPID-METABOLISM ; GENE-EXPRESSION ; ROS PRODUCTION ; TISSUE FACTOR ; OXIDIZED LDL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000246988600024 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.144/handle/331004/98]  |
| 专题 | 中国科学院上海生命科学研究院营养科学研究所_信号转导与营养相关疾病研究组 |
| 推荐引用方式 GB/T 7714 | Ding, Qiurong,Jin, Ting,Wang, Zhenzhen,et al. Catalase potentiates retinoic acid-induced THP-1 monocyte differentiation into macrophage through inhibition of peroxisome proliferator-activated receptor gamma[J]. JOURNAL OF LEUKOCYTE BIOLOGY,2007,81(6):1568-1576. |
| APA | Ding, Qiurong,Jin, Ting,Wang, Zhenzhen,&Chen, Yan.(2007).Catalase potentiates retinoic acid-induced THP-1 monocyte differentiation into macrophage through inhibition of peroxisome proliferator-activated receptor gamma.JOURNAL OF LEUKOCYTE BIOLOGY,81(6),1568-1576. |
| MLA | Ding, Qiurong,et al."Catalase potentiates retinoic acid-induced THP-1 monocyte differentiation into macrophage through inhibition of peroxisome proliferator-activated receptor gamma".JOURNAL OF LEUKOCYTE BIOLOGY 81.6(2007):1568-1576. |
入库方式： OAI收割
来源：上海营养与健康研究所
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