Structural dissection of Hippo signaling
文献类型：期刊论文
| 作者 | Shi, ZB; Jiao, S; Zhou, ZC |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2015 |
| 卷号 | 47期号:1页码:29-38 |
| 关键词 | Hippo pathway three-dimensional structure protein-protein DNA interaction regulatory mechanism |
| 通讯作者 | Zhou, ZC (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Natl Ctr Prot Sci Shanghai, State Key Lab Cell Biol,Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,zczhou@sibcb.ac.cn |
| 英文摘要 | The Hippo pathway controls cell number and organ size by restricting cell proliferation and promoting apoptosis, and thus is a key regulator in development and homeostasis. Dysfunction of the Hippo pathway correlates with many pathological conditions, especially cancer. Hippo signaling also plays important roles in tissue regeneration and stem cell biology. Therefore, the Hippo pathway is recognized as a crucial target for cancer therapy and regeneration medicine. To date, structures of several key components in Hippo signaling have been determined. In this review, we summarize current available structural studies of the Hippo pathway, which may help to improve our understanding of its regulatory mechanisms, as well as to facilitate further functional studies and potential therapeutic interventions. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | ORGAN SIZE CONTROL ; PROTEIN-INTERACTION NETWORK ; TEAD TRANSCRIPTION FACTORS ; TUMOR-SUPPRESSOR LATS1 ; CELL SELF-RENEWAL ; WW DOMAIN ; PROMOTES APOPTOSIS ; CRYSTAL-STRUCTURE ; DROSOPHILA-MELANOGASTER ; PROLIFERATION ARREST |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000347411100005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/11]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Shi, ZB,Jiao, S,Zhou, ZC. Structural dissection of Hippo signaling[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2015,47(1):29-38. |
| APA | Shi, ZB,Jiao, S,&Zhou, ZC.(2015).Structural dissection of Hippo signaling.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,47(1),29-38. |
| MLA | Shi, ZB,et al."Structural dissection of Hippo signaling".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 47.1(2015):29-38. |
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