Hsp90 alpha forms a stable complex at the cilium neck for the interaction of signalling molecules in IGF-1 receptor signalling
文献类型：期刊论文
| 作者 | Wang, HZ; Zou, XL; Wei, Z; Wu, Y; Li, RX; Zeng, R; Chen, ZJ; Liao, K |
| 刊名 | JOURNAL OF CELL SCIENCE
 |
| 出版日期 | 2015 |
| 卷号 | 128期号:1页码:100-108 |
| 关键词 | Akt-1 Hsp90 alpha IGF-1 receptor IRS-1 Primary cilium |
| 通讯作者 | Liao, K (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,kliao@sibs.ac.cn |
| 英文摘要 | The primary cilium is composed of an axoneme that protrudes from the cell surface, a basal body beneath the membrane and a transition neck in between. It is a sensory organelle on the plasma membrane, involved in mediating extracellular signals. In the transition neck region of the cilium, the microtubules change from triplet to doublet microtubules. This region also contains the transition fibres that crosslink the axoneme with the membrane and the necklace proteins that regulate molecules being transported into and out of the cilium. In this protein-enriched, complex area it is important to maintain the correct assembly of all of these proteins. Here, through immunofluorescent staining and protein isolation, we identify the molecular chaperone Hsp90 alpha clustered at the periciliary base. At the transition neck region, phosphorylated Hsp90 alpha forms a stable ring around the axoneme. Heat shock treatment causes Hsp90 alpha to dissipate and induces resorption of cilia. We further identify that Hsp90 alpha at the transition neck region represents a signalling platform on which IRS-1 interacts with intracellular downstream signalling molecules involved in IGF-1 receptor signalling. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | 3T3-L1 PREADIPOCYTE DIFFERENTIATION ; HSP90 ; CHAPERONE ; EXPRESSION ; INHIBITORS ; DROSOPHILA ; INDUCTION ; CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000347167200012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/13]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, HZ,Zou, XL,Wei, Z,et al. Hsp90 alpha forms a stable complex at the cilium neck for the interaction of signalling molecules in IGF-1 receptor signalling[J]. JOURNAL OF CELL SCIENCE,2015,128(1):100-108. |
| APA | Wang, HZ.,Zou, XL.,Wei, Z.,Wu, Y.,Li, RX.,...&Liao, K.(2015).Hsp90 alpha forms a stable complex at the cilium neck for the interaction of signalling molecules in IGF-1 receptor signalling.JOURNAL OF CELL SCIENCE,128(1),100-108. |
| MLA | Wang, HZ,et al."Hsp90 alpha forms a stable complex at the cilium neck for the interaction of signalling molecules in IGF-1 receptor signalling".JOURNAL OF CELL SCIENCE 128.1(2015):100-108. |
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