An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat
文献类型：期刊论文
| 作者 | Ru, YF; Xue, HM; Ni, ZM; Xia, D; Zhou, YC; Zhang, YL |
| 刊名 | ASIAN JOURNAL OF ANDROLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 17期号:2页码:292-297 |
| 关键词 | carboxylesterase CES5A epididymis male fertility sperm capacitation |
| 通讯作者 | Zhou, YC (reprint author), Chinese Acad Sci, Shanghai Key Lab Mol Androl, State Key Lab Mol Biol, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, Shanghai, Peoples R China.,zhouych@sibcb.ac.cn ; ylzhang@sibcb.ac.cn |
| 英文摘要 | Despite the fact that the phenomenon of capacitation was discovered over half century ago and much progress has been made in identifying sperm events involved in capacitation, few specific molecules of epididymal origin have been identified as being directly involved in this process in vivo . Previously, our group cloned and characterized a carboxyl esterase gene Ces5a in the rat epididymis. The CES5A protein is mainly expressed in the corpus and cauda epididymidis and secreted into the corresponding lumens. Here, we report the function of CES5A in sperm maturation. By local injection of Lentivirus -mediated siRNA in the CES5A -expressing region of the rat epididymis, Ces5a -knockdown animal models were created. These animals exhibited an inhibited sperm capacitation and a reduction in male fertility. These results suggest that CES5A plays an important role in sperm maturation and male fertility. |
| 学科主题 | Endocrinology & Metabolism; Urology & Nephrology |
| 类目[WOS] | Andrology ; Urology & Nephrology |
| 关键词[WOS] | PROTEIN-TYROSINE PHOSPHORYLATION ; DROSOPHILA-MELANOGASTER ; REPRODUCTIVE-SYSTEM ; MOUSE SPERMATOZOA ; MATURATION ; GENE ; CHOLESTEROL ; OVEREXPRESSION ; IDENTIFICATION ; LOCALIZATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000352069700025 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/18]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Ru, YF,Xue, HM,Ni, ZM,et al. An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat[J]. ASIAN JOURNAL OF ANDROLOGY,2015,17(2):292-297. |
| APA | Ru, YF,Xue, HM,Ni, ZM,Xia, D,Zhou, YC,&Zhang, YL.(2015).An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat.ASIAN JOURNAL OF ANDROLOGY,17(2),292-297. |
| MLA | Ru, YF,et al."An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat".ASIAN JOURNAL OF ANDROLOGY 17.2(2015):292-297. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。