Intrinsic regulations in neural fate commitment
文献类型：期刊论文
| 作者 | Tang, K; Peng, GD; Qiao, YB; Song, L; Jing, NH |
| 刊名 | DEVELOPMENT GROWTH & DIFFERENTIATION
 |
| 出版日期 | 2015 |
| 卷号 | 57期号:2页码:109-120 |
| 关键词 | embryonic stem cell epigenetic modification extracellular signals neural fate commitment transcription factor |
| 通讯作者 | Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,ktang.sc@gmail.com ; njing@sibcb.ac.cn |
| 英文摘要 | Neural fate commitment is an early embryonic event that a group of cells in ectoderm, which do not ingress through primitive streak, acquire a neural fate but not epidermal or mesodermal lineages. Several extracellular signaling pathways initiated by the secreted proteins bone morphogenetic proteins (BMPs), fibroblast growth factors (FGFs), wingless/int class proteins (WNTs) and Nodal play essential roles in the specification of the neural plate. Accumulating evidence from the studies on mouse and pluripotent embryonic stem cells reveals that except for the extracellular signals, the intracellular molecules, including both transcriptional and epigenetic factors, participate in the modulation of neural fate commitment as well. In the review, we mainly focus on recent findings that the initiation of the nervous system is elaborately regulated by the intrinsic programs, which are mediated by transcriptional factors such as Sox2, Zfp521, Sip1 and Pou3f1, as well as epigenetic modifications, including histone methylation/demethylation, histone acetylation/deacetylation, and DNA methylation/demethylation. The discovery of the intrinsic regulatory machineries provides better understanding of the mechanisms by which the neural fate commitment is ensured by the cooperation between extracellular factors and intracellular molecules. |
| 学科主题 | Cell Biology; Developmental Biology |
| 类目[WOS] | Cell Biology ; Developmental Biology |
| 关键词[WOS] | EMBRYONIC STEM-CELLS ; ZINC-FINGER PROTEIN ; MAMMALIAN DEVELOPMENT ; GENE-EXPRESSION ; MOUSE EMBRYO ; HISTONE H3 ; DEVELOPMENTAL REGULATORS ; TRANSCRIPTIONAL NETWORK ; LINEAGE SPECIFICATION ; POSTNATAL-DEVELOPMENT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350479100003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/21]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Tang, K,Peng, GD,Qiao, YB,et al. Intrinsic regulations in neural fate commitment[J]. DEVELOPMENT GROWTH & DIFFERENTIATION,2015,57(2):109-120. |
| APA | Tang, K,Peng, GD,Qiao, YB,Song, L,&Jing, NH.(2015).Intrinsic regulations in neural fate commitment.DEVELOPMENT GROWTH & DIFFERENTIATION,57(2),109-120. |
| MLA | Tang, K,et al."Intrinsic regulations in neural fate commitment".DEVELOPMENT GROWTH & DIFFERENTIATION 57.2(2015):109-120. |
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