Opioid receptor trafficking and interaction in nociceptors
文献类型：期刊论文
| 作者 | Zhang, X; Bao, L; Li, S |
| 刊名 | BRITISH JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 172期号:2页码:364-374 |
| 关键词 | -opioid receptor -opioid receptor nociceptor dorsal root ganglion receptor trafficking receptor interaction morphine antinociceptive tolerance |
| 通讯作者 | Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn |
| 英文摘要 | Opiate analgesics such as morphine are often used for pain therapy. However, antinociceptive tolerance and dependence may develop with long-term use of these drugs. It was found that -opioid receptors can interact with -opioid receptors, and morphine antinociceptive tolerance can be reduced by blocking -opioid receptors. Recent studies have shown that - and -opioid receptors are co-expressed in a considerable number of small neurons in the dorsal root ganglion. The interaction of -opioid receptors with -opioid receptors in the nociceptive afferents is facilitated by the stimulus-induced cell-surface expression of -opioid receptors, and contributes to morphine tolerance. Further analysis of the molecular, cellular and neural circuit mechanisms that regulate the trafficking and interaction of opioid receptors and related signalling molecules in the pain pathway would help to elucidate the mechanism of opiate analgesia and improve pain therapy. Linked ArticlesThis article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit |
| 学科主题 | Pharmacology & Pharmacy |
| 类目[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | DORSAL-ROOT GANGLIA ; PROTEIN-COUPLED RECEPTORS ; DENSE-CORE VESICLES ; SUBSTANCE-P RELEASE ; SPINAL-CORD ; MORPHINE-TOLERANCE ; SENSORY NEURONS ; MESSENGER-RNAS ; KNOCKOUT MICE ; MU-RECEPTOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000346826500013 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/26]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, X,Bao, L,Li, S. Opioid receptor trafficking and interaction in nociceptors[J]. BRITISH JOURNAL OF PHARMACOLOGY,2015,172(2):364-374. |
| APA | Zhang, X,Bao, L,&Li, S.(2015).Opioid receptor trafficking and interaction in nociceptors.BRITISH JOURNAL OF PHARMACOLOGY,172(2),364-374. |
| MLA | Zhang, X,et al."Opioid receptor trafficking and interaction in nociceptors".BRITISH JOURNAL OF PHARMACOLOGY 172.2(2015):364-374. |
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