Brahma regulates the Hippo pathway activity through forming complex with Yki-Sd and regulating the transcription of Crumbs
文献类型：期刊论文
| 作者 | Zhu, Y; Li, D; Wang, YD; Pei, CL; Liu, S; Zhang, L; Yuan, ZQ; Zhang, P |
| 刊名 | CELLULAR SIGNALLING
 |
| 出版日期 | 2015 |
| 卷号 | 27期号:3页码:606-613 |
| 关键词 | Brahma Growth control Yorkie Crumbs Feedback |
| 通讯作者 | Yuan, ZQ (reprint author), Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China.,zqyuan@ibp.ac.cn |
| 英文摘要 | The Hippo signaling pathway restricts organ size by inactivating the Yorkie (Yki)/Yes-associated protein (YAP) family proteins. The oncogenic Yki/YAP transcriptional coactivator family promotes tissue growth by activating target gene transcription, but the regulation of Yki/YAP activation remains elusive. In mammalian cells, we identified Brg1, a major subunit of chromatin-remodeling SWI/SNF family proteins, which interacts with YAP. This finding led us to investigate the in vivo functional interaction of Yki and Brahma (Brm), the Drosophila homolog of Brg1. We found that Brm functions at the downstream of Hippo pathway and interacts with Yki and Scalloped (Sd) to promotes Yki-dependent transcription and tissue growth. Furthermore, we demonstrated that Brm is required for the Crumbs (Crb) dysregulation-induced Yki activation. Interestingly, we also found that crb is a downstream target of Yki-Brm complex. Brm physically binds to the promoter of crb and regulates its transcription through Yki. Together, we showed that Brm functions as a critical regulator of Hippo signaling during tissue growth and plays an important role in the feedback loop between Crb and Yki. (C) 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | CHROMATIN-REMODELING COMPLEXES ; ORGAN SIZE CONTROL ; TUMOR-SUPPRESSOR ; CELL-PROLIFERATION ; SIGNALING PATHWAY ; SELF-RENEWAL ; STEM-CELLS ; DROSOPHILA ; FAMILY ; CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350707300022 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/35]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhu, Y,Li, D,Wang, YD,et al. Brahma regulates the Hippo pathway activity through forming complex with Yki-Sd and regulating the transcription of Crumbs[J]. CELLULAR SIGNALLING,2015,27(3):606-613. |
| APA | Zhu, Y.,Li, D.,Wang, YD.,Pei, CL.,Liu, S.,...&Zhang, P.(2015).Brahma regulates the Hippo pathway activity through forming complex with Yki-Sd and regulating the transcription of Crumbs.CELLULAR SIGNALLING,27(3),606-613. |
| MLA | Zhu, Y,et al."Brahma regulates the Hippo pathway activity through forming complex with Yki-Sd and regulating the transcription of Crumbs".CELLULAR SIGNALLING 27.3(2015):606-613. |
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