Identification of differentially expressed miRNAs in mouse spinal cord development
文献类型：期刊论文
| 作者 | Zhao, BT; Huang, MG; Bai, YY; Fan, CS; Fan, Y; Jin, YX |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2015 |
| 卷号 | 47期号:3页码:224-229 |
| 关键词 | miRNA spinal cord development miRNA microarray |
| 通讯作者 | Jin, YX (reprint author), Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China.,yi.fan@uphs.upenn.edu ; yxjin@sibs.ac.cn |
| 英文摘要 | MicroRNAs (miRNAs) are a class of non-coding, regulatory small RNAs of similar to 22 nt. It was implicated that these small RNAs play critical roles in various important biological processes. During development, some miRNAs are specifically expressed in individual tissues and at particular developmental stages. Many miRNAs show distinct expression patterns in the development of central nervous system, including spinal cord. In this study, we first reported the miRNAs expression in the development of mouse spinal cord. Differentially expressed miRNAs in embryonic (day 13.5) and neonatal mice spinal cords were identified. The predicted target genes of the differentially expressed miRNAs were subject to gene ontology and KEGG pathway analysis, and several nervous development-related pathways were enriched, implying that these miRNAs may be involved in these pathways that regulate mouse spinal cord development. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | CENTRAL-NERVOUS-SYSTEM ; MICRORNA TARGETS ; INJURY ; DYSREGULATION ; PREDICTION ; RESOURCE ; DISEASE ; CLUSTER ; UPDATE ; SITES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000351136700010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/36]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhao, BT,Huang, MG,Bai, YY,et al. Identification of differentially expressed miRNAs in mouse spinal cord development[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2015,47(3):224-229. |
| APA | Zhao, BT,Huang, MG,Bai, YY,Fan, CS,Fan, Y,&Jin, YX.(2015).Identification of differentially expressed miRNAs in mouse spinal cord development.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,47(3),224-229. |
| MLA | Zhao, BT,et al."Identification of differentially expressed miRNAs in mouse spinal cord development".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 47.3(2015):224-229. |
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