FXYD2, a gamma subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation
文献类型：期刊论文
| 作者 | Wang, F; Cai, B; Li, KC; Hu, XY; Lu, YJ; Wang, Q; Bao, L; Zhang, X |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2015 |
| 卷号 | 25期号:3页码:318-334 |
| 关键词 | FXYD2 Na+ inflammatory pain dorsal root ganglion K+-ATPase |
| 通讯作者 | Zhang, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Inst Neurosci, Shanghai 200031, Peoples R China.,xu.zhang@ion.ac.cn |
| 英文摘要 | Na+,K+-ATPase (NKA) is required to generate the resting membrane potential in neurons. Nociceptive afferent neurons express not only the alpha and beta subunits of NKA but also the gamma subunit FXYD2. However, the neural function of FXYD2 is unknown. The present study shows that FXYD2 in nociceptive neurons is necessary for maintaining the mechanical allodynia induced by peripheral inflammation. FXYD2 interacted with a1NKA and negatively regulated the NKA activity, depolarizing the membrane potential of nociceptive neurons. Mechanical allodynia initiated in FXYD2-deficient mice was abolished 4 days after inflammation, whereas it persisted for at least 3 weeks in wild-type mice. Importantly, the FXYD2/alpha 1NKA interaction gradually increased after inflammation and peaked on day 4 post inflammation, resulting in reduction of NKA activity, depolarization of neuron membrane and facilitation of excitatory afferent neurotransmission. Thus, the increased FXYD2 activity may be a fundamental mechanism underlying the persistent hypersensitivity to pain induced by inflammation. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | PERIPHERAL NERVOUS-SYSTEM ; ROOT GANGLIA NEURONS ; FOLLISTATIN-LIKE 1 ; ADENOSINE-TRIPHOSPHATASE ; AFFERENT NEURONS ; OPIOID RECEPTORS ; SENSORY NEURONS ; BETA-SUBUNIT ; SPINAL-CORD ; NA+/K+ PUMP |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350568800008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/38]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, F,Cai, B,Li, KC,et al. FXYD2, a gamma subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation[J]. CELL RESEARCH,2015,25(3):318-334. |
| APA | Wang, F.,Cai, B.,Li, KC.,Hu, XY.,Lu, YJ.,...&Zhang, X.(2015).FXYD2, a gamma subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation.CELL RESEARCH,25(3),318-334. |
| MLA | Wang, F,et al."FXYD2, a gamma subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation".CELL RESEARCH 25.3(2015):318-334. |
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