The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6
文献类型：期刊论文
| 作者 | Jiao, S; Zhang, Z; Li, CC; Huang, M; Shi, ZB; Wang, YY; Song, XM; Liu, H; Li, CY; Chen, M |
| 刊名 | NATURE IMMUNOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 16期号:3页码:246-U204 |
| 通讯作者 | Zhou, ZC (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Natl Ctr Prot Sci Shanghai, State Key Lab Cell Biol,Inst Biochem & Cell Biol, Shanghai, Peoples R China.,cwang01@sibcb.ac.cn ; zczhou@sibcb.ac.cn |
| 英文摘要 | Immune responses need to be tightly controlled to avoid excessive inflammation and prevent unwanted host damage. Here we report that germinal center kinase MST4 responded dynamically to bacterial infection and acted as a negative regulator of inflammation. We found that MST4 directly interacted with and phosphorylated the adaptor TRAF6 to prevent its oligomerization and autoubiquitination. Accordingly, MST4 did not inhibit lipopolysaccharide-induced cytokine production in Traf6(-/-) embryonic fibroblasts transfected to express a mutant form of TRAF6 that cannot be phosphorylated at positions 463 and 486 ( with substitution of alanine for threonine at those positions). Upon developing septic shock, mice in which MST4 was knocked down showed exacerbated inflammation and reduced survival, whereas heterozygous deletion of Traf6 (Traf6(+/-)) alleviated such deleterious effects. Our findings reveal a mechanism by which TRAF6 is regulated and highlight a role for MST4 in limiting inflammatory responses. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | NF-KAPPA-B ; STE20-RELATED KINASE ; PROVIDES INSIGHTS ; CELL-GROWTH ; I RECEPTOR ; ACTIVATION ; COMPLEX ; UBIQUITINATION ; MECHANISM ; CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000349842100008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/39]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Jiao, S,Zhang, Z,Li, CC,et al. The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6[J]. NATURE IMMUNOLOGY,2015,16(3):246-U204. |
| APA | Jiao, S.,Zhang, Z.,Li, CC.,Huang, M.,Shi, ZB.,...&Zhou, ZC.(2015).The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6.NATURE IMMUNOLOGY,16(3),246-U204. |
| MLA | Jiao, S,et al."The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6".NATURE IMMUNOLOGY 16.3(2015):246-U204. |
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