Upregulation of alphaB-crystallin expression in the substantia nigra of patients with Parkinson's disease
文献类型：期刊论文
| 作者 | Liu, YJ; Zhou, QB; Tang, M; Fu, N; Shao, W; Zhang, SZ; Yin, YQ; Zeng, R; Wang, XM; Hu, G |
| 刊名 | NEUROBIOLOGY OF AGING
 |
| 出版日期 | 2015 |
| 卷号 | 36期号:4页码:1686-1691 |
| 关键词 | Parkinson's disease Quantitative proteomics Human AlphaB-crystallin Glial cells |
| 通讯作者 | Zhou, JW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,jwzhou@ion.ac.cn |
| 英文摘要 | Parkinson's disease (PD) is one of the most devastating neurodegenerative disorders. The underlying mechanisms of the characteristic neurodegeneration in the substantia nigra (SN) are still not fully understood. To better understand the molecular events occurring in the SN of PD brain, we used the culture-derived isotope tag-based quantitative proteomics to compare the protein expression profiles in the nigral tissue of PD patients and control subjects. We identified a total of 11 differentially expressed proteins, including alphaB-crystallin (Cryab). Both the levels and pattern of Cryab expression in the SN were validated. It was revealed that Cryab was markedly upregulated in the SN of PD brain. Cryab expression was also upregulated in reactive astrocytes and microglia in a neurotoxin-induced mouse PD model. Moreover, we showed increased expression of Cryab in cytoplasmic inclusions in a subset of glial cells in Parkinsonian brain. Thus, we identified Cryab that is highly expressed in the SN of PD brain and may be involved in the glial pathology during dopaminergic neuron degeneration in PD. (C) 2015 Elsevier Inc. All rights reserved. |
| 学科主题 | Geriatrics & Gerontology ; Neurosciences & Neurology |
| 类目[WOS] | Geriatrics & Gerontology ; Neurosciences |
| 关键词[WOS] | PROTEASOME ACTIVATOR PA28 ; HEAT-SHOCK PROTEINS ; B-CRYSTALLIN ; PROGESTERONE-ANTAGONISM ; MICROGLIAL ACTIVATION ; ACUTE-INFLAMMATION ; LINK PROTEIN ; BRAIN ; NEURONS ; COMPLEX |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000355095300009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/47]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, YJ,Zhou, QB,Tang, M,et al. Upregulation of alphaB-crystallin expression in the substantia nigra of patients with Parkinson's disease[J]. NEUROBIOLOGY OF AGING,2015,36(4):1686-1691. |
| APA | Liu, YJ.,Zhou, QB.,Tang, M.,Fu, N.,Shao, W.,...&Zhou, JW.(2015).Upregulation of alphaB-crystallin expression in the substantia nigra of patients with Parkinson's disease.NEUROBIOLOGY OF AGING,36(4),1686-1691. |
| MLA | Liu, YJ,et al."Upregulation of alphaB-crystallin expression in the substantia nigra of patients with Parkinson's disease".NEUROBIOLOGY OF AGING 36.4(2015):1686-1691. |
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