UXT potentiates angiogenesis by attenuating Notch signaling
文献类型：期刊论文
| 作者 | Zhou, Y; Ge, R; Wang, R; Liu, F; Huang, YF; Liu, H; Hao, Y; Zhou, Q; Wang, C |
| 刊名 | DEVELOPMENT
 |
| 出版日期 | 2015 |
| 卷号 | 142期号:4页码:774-786 |
| 关键词 | Notch signaling Angiogenesis UXT Zebrafish HUVECs |
| 通讯作者 | Zhou, Q (reprint author), Chongqing Med Univ, Div Mol Nephrol, Chongqing 400016, Peoples R China.,zhouqin@cqmu.edu.cn ; cwang01@sibcb.ac.cn |
| 英文摘要 | Angiogenesis is spatially and temporally orchestrated by a myriad of signaling pathways, including the Notch signaling pathway. Here, we identified UXT as an evolutionarily conserved and developmentally expressed protein, indispensable for intersegmental vessel (ISV) formation in zebrafish. Deficiency of UXT in zebrafish embryos results in shorter ISVs, loss of tip cell behavior, and impairment of endothelial cell migration and division. Significantly, UXT attenuates the expression of the Notch-responsive genes in vitro and in vivo. Mechanistically, UXT binds to the promoters of the Notch signaling target genes and specifically interacts with the transactivation region domain of the Notch intracellular domain (NICD), impairing the interaction between NICD and the transcription factor RBP-J kappa endogenously. This prevents RBP-J kappa/CSL from activation and thus inhibits the consequent gene inductions. Furthermore, blockade of Notch signaling rescues the angiogenesis defect caused by UXT knockdown both in vitro and in vivo. Taken together, the data presented in this study characterize UXT as a novel repressor of Notch signaling, shedding new light on the molecular regulation of angiogenesis. |
| 学科主题 | Developmental Biology |
| 类目[WOS] | Developmental Biology |
| 关键词[WOS] | EMBRYONIC VASCULAR DEVELOPMENT ; TUMOR ANGIOGENESIS ; ENDOTHELIAL-CELLS ; ZEBRAFISH ; RECEPTOR ; PROTEIN ; COMPLEX ; GENES ; VEGF ; PATHWAY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000351697100018 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/55]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhou, Y,Ge, R,Wang, R,et al. UXT potentiates angiogenesis by attenuating Notch signaling[J]. DEVELOPMENT,2015,142(4):774-786. |
| APA | Zhou, Y.,Ge, R.,Wang, R.,Liu, F.,Huang, YF.,...&Wang, C.(2015).UXT potentiates angiogenesis by attenuating Notch signaling.DEVELOPMENT,142(4),774-786. |
| MLA | Zhou, Y,et al."UXT potentiates angiogenesis by attenuating Notch signaling".DEVELOPMENT 142.4(2015):774-786. |
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