The Combination of Aricept with a Traditional Chinese Medicine Formula, Smart Soup, May Be a Novel Way to Treat Alzheimer's Disease
文献类型：期刊论文
| 作者 | Wang, Y; Wang, Y; Sui, Y; Yu, HS; Shen, XH; Chen, SD; Pei, G; Zhao, J; Ding, JQ |
| 刊名 | JOURNAL OF ALZHEIMERS DISEASE
 |
| 出版日期 | 2015 |
| 卷号 | 45期号:4页码:1185-1195 |
| 关键词 | Alzheimer's disease Traditional Chinese Medicine Smart Soup (SS) Aricept combination therapy |
| 通讯作者 | Ding, JQ (reprint author), Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Inst Neurol, Shanghai 200025, Peoples R China.,jzhao@sibs.ac.cn ; jqding18@163.com |
| 英文摘要 | Alzheimer's disease (AD) is a common neurodegenerative disease affecting cognitive function in the elderly, which is characterized by the presence of extracellular deposits of insoluble amyloid-beta plaques and neuronal loss. Modern pharmacology and drug development usually follow a single-target principle, which might contribute to the failure of most compounds in clinical trials against AD. Considering AD is a multifactorial disease, a combination therapeutic strategy that applies drugs with different mechanisms would be an alternative way. Smart Soup (SS), a Traditional Chinese Medicine formula, is composed of three herbaceous plants and has been applied in the treatment of amnesia in China for hundreds of years. In this work, we studied the clinical potency of the combination of SS and Aricept in AD therapy. In the in vivo model, both longevity and locomotive activity of AD transgenic Drosophila were improved remarkably in the combined medicine treated group. We also observed less amyloid-beta deposition and retarded neuronal loss following the combined drug treatment. In the retrospective cohort study, we found the combination therapy exerted better therapeutic effect on AD patients. Our study revealed that combination therapy with multiple drug targets did have a better therapeutic outcome. It provides a new strategy to develop an optimum pharmaceutical approach against AD. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | DOUBLE-BLIND ; HERBAL MEDICINE ; DEMENTIA ; DROSOPHILA ; DONEPEZIL ; SYMPTOMS ; TRIAL ; EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000352819200018 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/57]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Y,Wang, Y,Sui, Y,et al. The Combination of Aricept with a Traditional Chinese Medicine Formula, Smart Soup, May Be a Novel Way to Treat Alzheimer's Disease[J]. JOURNAL OF ALZHEIMERS DISEASE,2015,45(4):1185-1195. |
| APA | Wang, Y.,Wang, Y.,Sui, Y.,Yu, HS.,Shen, XH.,...&Ding, JQ.(2015).The Combination of Aricept with a Traditional Chinese Medicine Formula, Smart Soup, May Be a Novel Way to Treat Alzheimer's Disease.JOURNAL OF ALZHEIMERS DISEASE,45(4),1185-1195. |
| MLA | Wang, Y,et al."The Combination of Aricept with a Traditional Chinese Medicine Formula, Smart Soup, May Be a Novel Way to Treat Alzheimer's Disease".JOURNAL OF ALZHEIMERS DISEASE 45.4(2015):1185-1195. |
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