中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Integrated Analysis of Transcriptome in Cancer Patient-Derived Xenografts

文献类型:期刊论文

作者Li, H; Zhu, YJ; Tang, XY; Li, JY; Li, YY; Zhong, ZM; Ding, GH; Li, YX
刊名PLOS ONE
出版日期2015
卷号10期号:5页码:e0126492-e0126492
通讯作者Ding, GH (reprint author), Chinese Acad Sci, SIBS, Inst Biochem & Cell Biol, Key Lab Syst Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,gwding@sibs.ac.cn ; yxli@sibs.ac.cn
英文摘要Patient-derived xenograft (PDX) tumor model is a powerful technology in evaluating anticancer drugs and facilitating personalized medicines. Multiple research centers and commercial companies have put huge efforts into building PDX mouse models. However, PDX models have not been widely available and their molecular features have not been systematically characterized. In this study, we provided a comprehensive survey of PDX transcriptome by integrating analysis of 58 patients involving 8 different tumors. The median correlation coefficient between patients and xenografts is 0.94, which is higher than that between patients and cell line panel or between patients with the same tumor. Major differential gene expressions in PDX occur in the engraftment of human tumor tissue into mice, while gene expressions are relatively stable over passages. 48 genes are frequently differentially expressed in PDX mice of multiple cancers. They are enriched in extracellular matrix and immune response, and some are reported as targets for anticancer drugs. A simulation study showed that expression change between PDX and patient tumor (6%) would result in acceptable change in drug sensitivity (3%). Our findings demonstrate that PDX mice represent the gene-expression and drug-response features of primary tumors effectively, and it is recommended to monitoring the overall expression profiles and drug target genes in clinical application.
学科主题Science & Technology - Other Topics
类目[WOS]Multidisciplinary Sciences
关键词[WOS]TUMOR XENOGRAFTS ; NUDE-MICE ; GENE ; MODELS ; SIGNATURES ; THERAPY
收录类别SCI
语种英语
WOS记录号WOS:000354214400019
版本出版稿
源URL[http://202.127.25.143/handle/331003/63]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式
GB/T 7714
Li, H,Zhu, YJ,Tang, XY,et al. Integrated Analysis of Transcriptome in Cancer Patient-Derived Xenografts[J]. PLOS ONE,2015,10(5):e0126492-e0126492.
APA Li, H.,Zhu, YJ.,Tang, XY.,Li, JY.,Li, YY.,...&Li, YX.(2015).Integrated Analysis of Transcriptome in Cancer Patient-Derived Xenografts.PLOS ONE,10(5),e0126492-e0126492.
MLA Li, H,et al."Integrated Analysis of Transcriptome in Cancer Patient-Derived Xenografts".PLOS ONE 10.5(2015):e0126492-e0126492.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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