Inhibition of Transforming Growth Factor beta (TGF-beta) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency
文献类型：期刊论文
| 作者 | Tan, FZ; Qian, C; Tang, K; Abd-Allah, SM; Jing, NH |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 290期号:7页码:4500-4511 |
| 通讯作者 | Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,njing@sibcb.ac.cn |
| 英文摘要 | Mouse pluripotent stem cells (PSCs), such as ES cells and induced PSCs (iPSCs), are an excellent system to investigate the molecular and cellular mechanisms involved in early embryonic development. The signaling pathways orchestrated by leukemia inhibitor factor/STAT3, Wnt/beta-catenin, and FGF/MEK/ERK play key roles in the generation of pluripotency. However, the function of TGF-beta signaling in this process remains elusive. Here we show that inhibiting TGF-beta signaling with its inhibitor SB431542 can substitute for Oct4 during reprogramming. Moreover, inhibiting TGF-beta signaling can sustain the pluripotency of iPSCs and ES cells through modulating FGF/MEK/ERK signaling. Therefore, this study reveals a novel function of TGF-beta signaling inhibition in the generation and maintenance of PSCs. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | EMBRYONIC STEM-CELLS ; MOUSE SOMATIC-CELLS ; GROUND-STATE PLURIPOTENCY ; SMALL-MOLECULE COMPOUNDS ; EXTRACELLULAR-MATRIX ; PRIMITIVE ENDODERM ; HUMAN FIBROBLASTS ; DEFINED FACTORS ; SELF-RENEWAL ; DIFFERENTIATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000349458400055 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/84]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Tan, FZ,Qian, C,Tang, K,et al. Inhibition of Transforming Growth Factor beta (TGF-beta) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2015,290(7):4500-4511. |
| APA | Tan, FZ,Qian, C,Tang, K,Abd-Allah, SM,&Jing, NH.(2015).Inhibition of Transforming Growth Factor beta (TGF-beta) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency.JOURNAL OF BIOLOGICAL CHEMISTRY,290(7),4500-4511. |
| MLA | Tan, FZ,et al."Inhibition of Transforming Growth Factor beta (TGF-beta) Signaling can Substitute for Oct4 Protein in Reprogramming and Maintain Pluripotency".JOURNAL OF BIOLOGICAL CHEMISTRY 290.7(2015):4500-4511. |
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