A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells
文献类型：期刊论文
| 作者 | Ding, M; Lin, BY; Li, T; Liu, YY; Li, YH; Zhou, XY; Miao, MH; Gu, JF; Pan, HJ; Yang, F |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:10页码:7686-7700 |
| 关键词 | miR-204 XRN1 Prostate cancer |
| 通讯作者 | Li, RS (reprint author), WHO Collaborating Ctr Res Human Reprod, Shanghai, Peoples R China.,xyliu@sibs.ac.cn |
| 英文摘要 | Androgen deprivation therapy in prostate cancer (PCa) causes neuroendocrine differentiation (NED) of prostatic adenocarcinomas (PAC) cells, leading to recurrence of PCa. Androgen-responsive genes involved in PCa progression including NED remain largely unknown. Here we demonstrated the importance of androgen receptor (AR)-microRNA-204 (miR-204)-XRN1 axis in PCa cell lines and the rat ventral prostate. Androgens downregulate miR-204, resulting in induction of XRN1 (5'-3' exoribonuclease 1), which we identified as a miR-204 target. miR-204 acts as a tumor suppressor in two PAC cell lines (LNCaP and 22Rv1) and as an oncomiR in two neuroendocrine-like prostate cancer (NEPC) cell lines (PC-3 and CL1). Importantly, overexpression of miR-204 and knockdown of XRN1 inhibited AR expression in PCa cells. Repression of miR-34a, a known AR-targeting miRNA, contributes AR expression by XRN1. Thus we revealed the AR-miR-204-XRN1-miR-34a positive feedback loop and a dual function of miR-204/XRN1 axis in prostate cancer. |
| 学科主题 | Oncology ; Cell Biology |
| 类目[WOS] | Oncology ; Cell Biology |
| 关键词[WOS] | ANDROGEN-DEPRIVATION THERAPY ; EXPRESSION ; CARCINOMA ; RECEPTOR ; DIFFERENTIATION ; MIR-34A ; CD44 ; GENE ; INACTIVATION ; PROGRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354885300025 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/91]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Ding, M,Lin, BY,Li, T,et al. A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells[J]. ONCOTARGET,2015,6(10):7686-7700. |
| APA | Ding, M.,Lin, BY.,Li, T.,Liu, YY.,Li, YH.,...&Li, RS.(2015).A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells.ONCOTARGET,6(10),7686-7700. |
| MLA | Ding, M,et al."A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells".ONCOTARGET 6.10(2015):7686-7700. |
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