Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier
文献类型：期刊论文
| 作者 | Dai, B; Li, D; Xi, W; Luo, F; Zhang, X; Zou, M; Cao, M; Hu, J; Wang, WY; Wei, GH |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2015 |
| 卷号 | 112期号:10页码:2996-3001 |
| 关键词 | functional amyloid material peptide self-assembly nanosheet retrovirus transduction beta-amyloid |
| 通讯作者 | Wei, GH (reprint author), Fudan Univ, Dept Phys, Minist Educ, State Key Lab Surface Phys,Key Lab Computat Phys, Shanghai 200433, Peoples R China.,ghwei@fudan.edu.cn ; zhangyi@sinap.ac.cn ; liulab@sioc.ac.cn |
| 英文摘要 | Using and engineering amyloid as nanomaterials are blossoming trends in bionanotechnology. Here, we show our discovery of an amyloid structure, termed "amyloid-like nanosheet," formed by a key amyloid-forming segment of Alzheimer's A beta. Combining multiple biophysical and computational approaches, we proposed a structural model for the nanosheet that is formed by stacking the amyloid fibril spines perpendicular to the fibril axis. We further used the nanosheet for laboratorial retroviral transduction enhancement and directly visualized the presence of virus on the nanosheet surface by electron microscopy. Furthermore, based on our structural model, we designed nanosheet-forming peptides with different functionalities, elucidating the potential of rational design for amyloid-based materials with novel architecture and function. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | BUILDING-BLOCKS ; FIBRILS ; PROTEINS ; NANOTUBES ; DISEASE ; NANOMATERIALS ; DESIGN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350646500037 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/92]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Dai, B,Li, D,Xi, W,et al. Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2015,112(10):2996-3001. |
| APA | Dai, B.,Li, D.,Xi, W.,Luo, F.,Zhang, X.,...&Liu, C.(2015).Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,112(10),2996-3001. |
| MLA | Dai, B,et al."Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112.10(2015):2996-3001. |
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