TRIM35 negatively regulates TLR7-and TLR9-mediated type I interferon production by targeting IRF7
文献类型：期刊论文
| 作者 | Wang, YM; Yan, SS; Yang, B; Wang, Y; Zhou, HY; Lian, QS; Sun, B |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2015 |
| 卷号 | 589期号:12页码:1322-1330 |
| 关键词 | TRIM35 TLR7/9 IRF7 K48-linked ubiquitination Proteasome-dependent degradation Feedback regulation |
| 通讯作者 | Sun, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,bsun@sibs.ac.cn |
| 英文摘要 | Toll-like receptor 7 (TLR7) and TLR9 sense viral nucleic acids and induce type I IFN production, which must be properly controlled to avoid autoimmune diseases. Here, we report the negative regulation of TLR7/9-mediated type I IFN production by TRIM35. TRIM35 expression is induced by TLR7/9 stimulation and then interacts with IRF7, which is the master regulator of type I IFN response. Furthermore, TRIM35 promotes the K48-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway. Therefore, TRIM35 is a negative feedback regulator of TLR7/9-mediated type I IFN production due to its ability to suppress the stability of IRF7. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | PATTERN-RECOGNITION RECEPTORS ; PLASMACYTOID DENDRITIC CELLS ; TRANSCRIPTION FACTORS ; MEDIATED DEGRADATION ; PATHOGEN RECOGNITION ; ANTIVIRAL RESPONSE ; SIGNALING PATHWAYS ; FAMILY PROTEINS ; INNATE IMMUNITY ; B-BOX |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354290500006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/95]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, YM,Yan, SS,Yang, B,et al. TRIM35 negatively regulates TLR7-and TLR9-mediated type I interferon production by targeting IRF7[J]. FEBS LETTERS,2015,589(12):1322-1330. |
| APA | Wang, YM.,Yan, SS.,Yang, B.,Wang, Y.,Zhou, HY.,...&Sun, B.(2015).TRIM35 negatively regulates TLR7-and TLR9-mediated type I interferon production by targeting IRF7.FEBS LETTERS,589(12),1322-1330. |
| MLA | Wang, YM,et al."TRIM35 negatively regulates TLR7-and TLR9-mediated type I interferon production by targeting IRF7".FEBS LETTERS 589.12(2015):1322-1330. |
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