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Identification of multipotent mammary stemcells by protein C receptor expression
文献类型：期刊论文
| 作者 | Wang, DS; Cai, CG; Dong, XB; Yu, QC; Zhang, XO; Yang, L; Zeng, YA |
| 刊名 | NATURE
 |
| 出版日期 | 2015 |
| 卷号 | 517期号:7532页码:81-U201 |
| 通讯作者 | Zeng, YA (reprint author), Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,yzeng@sibcb.ac.cn |
| 英文摘要 | The mammary gland is composed of multiple types of epithelial cells, which are generated by mammary stem cells (MaSCs) residing at the top of the hierarchy(1,2). However, the existence of these multi-potent MaSCs remains controversial and the nature of such cells is unknown(3,4). Here we demonstrate that protein C receptor (Procr), a novel Wnt target in the mammary gland, marks a unique population of multipotent mouse MaSCs. Procr-positive cells localize to the basal layer, exhibit epithelial-to-mesenchymal transition characteristics, and express low levels of basal keratins. Procr-expressing cells have a high regenerative capacity in transplantation assays and differentiate into all lineages of the mammary epithelium by lineage tracing. These results define a novel multipotent mammary stem cell population that could be important in the initiation of breast cancer. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | STEM-CELLS ; WNT PROTEINS ; GLAND ; LINEAGES ; MOUSE ; BASAL ; GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000347178400039 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/102]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, DS,Cai, CG,Dong, XB,et al. Identification of multipotent mammary stemcells by protein C receptor expression[J]. NATURE,2015,517(7532):81-U201. |
| APA | Wang, DS.,Cai, CG.,Dong, XB.,Yu, QC.,Zhang, XO.,...&Zeng, YA.(2015).Identification of multipotent mammary stemcells by protein C receptor expression.NATURE,517(7532),81-U201. |
| MLA | Wang, DS,et al."Identification of multipotent mammary stemcells by protein C receptor expression".NATURE 517.7532(2015):81-U201. |
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