Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging
文献类型：期刊论文
| 作者 | Wei, YN; Hu, HY; Xie, GC; Fu, N; Ning, ZB; Zeng, R; Khaitovich, P |
| 刊名 | GENOME BIOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 16期号:1页码:41-41 |
| 通讯作者 | Zeng, R (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,zr@sibcb.ac.cn |
| 英文摘要 | Background: In studies of development and aging, the expression of many genes has been shown to undergo drastic changes at mRNA and protein levels. The connection between mRNA and protein expression level changes, as well as the role of posttranscriptional regulation in controlling expression level changes in postnatal development and aging, remains largely unexplored. Results: Here, we survey mRNA and protein expression changes in the prefrontal cortex of humans and rhesus macaques over developmental and aging intervals of both species' lifespans. We find substantial decoupling of mRNA and protein expression levels in aging, but not in development. Genes showing increased mRNA/protein disparity in primate brain aging form expression patterns conserved between humans and macaques and are enriched in specific functions involving mammalian target of rapamycin ( mTOR) signaling, mitochondrial function and neurodegeneration. Mechanistically, aging-dependent mRNA/protein expression decoupling could be linked to a specific set of RNA binding proteins and, to a lesser extent, to specific microRNAs. Conclusions: Increased decoupling of mRNA and protein expression profiles observed in human and macaque brain aging results in specific co-expression profiles composed of genes with shared functions and shared regulatory signals linked to specific posttranscriptional regulators. Genes targeted and predicted to be targeted by the aging-dependent posttranscriptional regulation are associated with biological processes known to play important roles in aging and lifespan extension. These results indicate the potential importance of posttranscriptional regulation in modulating aging-dependent changes in humans and other species. |
| 学科主题 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 关键词[WOS] | EXTENDS LIFE-SPAN ; MESSENGER-RNA ; ALZHEIMERS-DISEASE ; MAMMALIAN TARGET ; GENE-REGULATION ; HUMAN BRAIN ; CAENORHABDITIS-ELEGANS ; MOLECULAR-MECHANISMS ; FUNCTIONAL GENOMICS ; STRESS RESISTANCE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000351822800001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/106]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wei, YN,Hu, HY,Xie, GC,et al. Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging[J]. GENOME BIOLOGY,2015,16(1):41-41. |
| APA | Wei, YN.,Hu, HY.,Xie, GC.,Fu, N.,Ning, ZB.,...&Khaitovich, P.(2015).Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging.GENOME BIOLOGY,16(1),41-41. |
| MLA | Wei, YN,et al."Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging".GENOME BIOLOGY 16.1(2015):41-41. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。