中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging

文献类型:期刊论文

作者Wei, YN; Hu, HY; Xie, GC; Fu, N; Ning, ZB; Zeng, R; Khaitovich, P
刊名GENOME BIOLOGY
出版日期2015
卷号16期号:1页码:41-41
通讯作者Zeng, R (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,zr@sibcb.ac.cn
英文摘要Background: In studies of development and aging, the expression of many genes has been shown to undergo drastic changes at mRNA and protein levels. The connection between mRNA and protein expression level changes, as well as the role of posttranscriptional regulation in controlling expression level changes in postnatal development and aging, remains largely unexplored. Results: Here, we survey mRNA and protein expression changes in the prefrontal cortex of humans and rhesus macaques over developmental and aging intervals of both species' lifespans. We find substantial decoupling of mRNA and protein expression levels in aging, but not in development. Genes showing increased mRNA/protein disparity in primate brain aging form expression patterns conserved between humans and macaques and are enriched in specific functions involving mammalian target of rapamycin ( mTOR) signaling, mitochondrial function and neurodegeneration. Mechanistically, aging-dependent mRNA/protein expression decoupling could be linked to a specific set of RNA binding proteins and, to a lesser extent, to specific microRNAs. Conclusions: Increased decoupling of mRNA and protein expression profiles observed in human and macaque brain aging results in specific co-expression profiles composed of genes with shared functions and shared regulatory signals linked to specific posttranscriptional regulators. Genes targeted and predicted to be targeted by the aging-dependent posttranscriptional regulation are associated with biological processes known to play important roles in aging and lifespan extension. These results indicate the potential importance of posttranscriptional regulation in modulating aging-dependent changes in humans and other species.
学科主题Biotechnology & Applied Microbiology ; Genetics & Heredity
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]EXTENDS LIFE-SPAN ; MESSENGER-RNA ; ALZHEIMERS-DISEASE ; MAMMALIAN TARGET ; GENE-REGULATION ; HUMAN BRAIN ; CAENORHABDITIS-ELEGANS ; MOLECULAR-MECHANISMS ; FUNCTIONAL GENOMICS ; STRESS RESISTANCE
收录类别SCI
语种英语
WOS记录号WOS:000351822800001
版本出版稿
源URL[http://202.127.25.143/handle/331003/106]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
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GB/T 7714
Wei, YN,Hu, HY,Xie, GC,et al. Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging[J]. GENOME BIOLOGY,2015,16(1):41-41.
APA Wei, YN.,Hu, HY.,Xie, GC.,Fu, N.,Ning, ZB.,...&Khaitovich, P.(2015).Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging.GENOME BIOLOGY,16(1),41-41.
MLA Wei, YN,et al."Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging".GENOME BIOLOGY 16.1(2015):41-41.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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