Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis
文献类型：期刊论文
| 作者 | Wang, C; Zhang, WX; Yin, MX; Hu, LX; Li, PX; Xu, JJ; Huang, HL; Wang, SM; Lu, Y; Wu, WQ |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:1页码:6607-6607 |
| 通讯作者 | Zhang, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,rayzhang@sibcb.ac.cn |
| 英文摘要 | Pez functions as an upstream negative regulator of Yorkie (Yki) to regulate intestinal stem cell (ISC) proliferation and is essential for the activity of the Hippo pathway specifically in the Drosophila midgut epithelium. Here we report that Suppressor of Deltex (Su(dx)) acts as a negative regulator of Pez. We show that Su(dx) targets Pez for degradation both in vitro and in vivo. Overexpression of Su(dx) induces proliferation in the fly midgut epithelium, which can be rescued by overexpressed Pez. We also demonstrate that the interaction between Su(dx) and Pez, bridged by WW domains and PY/PPxY motifs, is required for Su(dx)-mediated Pez degradation. Furthermore, we find that Kibra, a binding partner of Pez, stabilizes Pez via WW-PY/PPxY interaction. Moreover, PTPN14, a Pez mammalian homolog, is degraded by overexpressed Su(dx) or Su(dx) homologue WWP1 in mammalian cells. These results reveal a previously unrecognized mechanism of Pez degradation in maintaining the homeostasis of Drosophila midgut. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | STEM-CELL PROLIFERATION ; UBIQUITIN LIGASE ; BREAST-CANCER ; HIPPO PATHWAY ; TGF-BETA ; PROTEIN ; GENE ; REGULATOR ; WWP1 ; DOMAINS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353040500002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/110]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, C,Zhang, WX,Yin, MX,et al. Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis[J]. NATURE COMMUNICATIONS,2015,6(1):6607-6607. |
| APA | Wang, C.,Zhang, WX.,Yin, MX.,Hu, LX.,Li, PX.,...&Zhang, L.(2015).Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis.NATURE COMMUNICATIONS,6(1),6607-6607. |
| MLA | Wang, C,et al."Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis".NATURE COMMUNICATIONS 6.1(2015):6607-6607. |
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