Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate
文献类型：期刊论文
| 作者 | Liu, PY; Dou, XY; Liu, C; Wang, LB; Xing, C; Peng, GD; Chen, J; Yu, F; Qiao, YB; Song, L |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:1页码:6830-6830 |
| 通讯作者 | Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,njing@sibcb.ac.cn |
| 英文摘要 | Cell fate determination requires the cooperation between extrinsic signals and intrinsic molecules including transcription factors as well as epigenetic regulators. Nevertheless, how neural fate commitment is regulated by epigenetic modifications remains largely unclear. Here we show that transient histone deacetylation at epiblast stage promotes neural differentiation of mouse embryonic stem cells (mESCs). Histone deacetylase 1 (HDAC1) deficiency in mESCs partially phenocopies the inhibition of histone deacetylation in vitro, and displays reduced incorporation into neural tissues in chimeric mouse embryos in vivo. Mechanistic studies show that Nodal, which is repressed by histone deacetylation, is a direct target of HDAC1. Furthermore, the inhibition of histone deacetylation in the anterior explant of mouse embryos at E7.0 leads to Nodal activation and neural development repression. Thus, our study reveals an intrinsic mechanism that epigenetic histone deacetylation ensures neural fate commitment by restricting Nodal signalling in murine anterior epiblast ex vivo and mESC in vitro. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | EMBRYONIC STEM-CELLS ; PROGENITOR CELLS ; DEFINITIVE ENDODERM ; BRAIN-DEVELOPMENT ; VISCERAL ENDODERM ; DIFFERENTIATION ; EPIBLAST ; INHIBITION ; HDAC2 ; GASTRULATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353703200009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/111]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, PY,Dou, XY,Liu, C,et al. Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate[J]. NATURE COMMUNICATIONS,2015,6(1):6830-6830. |
| APA | Liu, PY.,Dou, XY.,Liu, C.,Wang, LB.,Xing, C.,...&Jing, NH.(2015).Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate.NATURE COMMUNICATIONS,6(1),6830-6830. |
| MLA | Liu, PY,et al."Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate".NATURE COMMUNICATIONS 6.1(2015):6830-6830. |
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