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Complementary Sequence-Mediated Exon Circularization
文献类型：期刊论文
| 作者 | Zhang, XO; Wang, HB; Zhang, Y; Lu, XH; Chen, LL; Yang, L |
| 刊名 | CELL
 |
| 出版日期 | 2014 |
| 卷号 | 159期号:1页码:134-147 |
| 通讯作者 | Chen, LL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Shanghai Key Lab Mol Andro, Shanghai 200031, Peoples R China.,linglingchen@sibcb.ac.cn ; liyang@picb.ac.cn |
| 英文摘要 | Exon circularization has been identified from many loci in mammals, but the detailed mechanism of its biogenesis has remained elusive. By using genome-wide approaches and circular RNA recapitulation, we demonstrate that exon circularization is dependent on flanking intronic complementary sequences. Such sequences and their distribution exhibit rapid evolutionary changes, showing that exon circularization is evolutionarily dynamic. Strikingly, exon circularization efficiency can be regulated by competition between RNA pairing across flanking introns or within individual introns. Importantly, alternative formation of inverted repeated Alu pairs and the competition between them can lead to alternative circularization, resulting in multiple circular RNA transcripts produced from a single gene. Collectively, exon circularization mediated by complementary sequences in human introns and the potential to generate alternative circularization products extend the complexity of mammalian posttranscriptional regulation. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | INVERTED REPEATS ; RNA MOLECULES ; MOUSE TESTIS ; IDENTIFICATION ; TRANSCRIPTS ; ALGORITHM ; FUSION ; SRY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000343095000015 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/119]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, XO,Wang, HB,Zhang, Y,et al. Complementary Sequence-Mediated Exon Circularization[J]. CELL,2014,159(1):134-147. |
| APA | Zhang, XO,Wang, HB,Zhang, Y,Lu, XH,Chen, LL,&Yang, L.(2014).Complementary Sequence-Mediated Exon Circularization.CELL,159(1),134-147. |
| MLA | Zhang, XO,et al."Complementary Sequence-Mediated Exon Circularization".CELL 159.1(2014):134-147. |
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