Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression
文献类型：期刊论文
| 作者 | Liu, ZZ; Chen, P; Gao, H; Gu, Y; Yang, J; Peng, H; Xu, XX; Wang, HF; Yang, MQ; Liu, XY |
| 刊名 | CANCER CELL
 |
| 出版日期 | 2014 |
| 卷号 | 26期号:1页码:106-120 |
| 通讯作者 | Hu, RG (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,coryhu@sibs.ac.cn |
| 英文摘要 | In selective autophagy, receptors are central for cargo selection and delivery. However, it remains yet unclear whether and how multiple autophagy receptors might form complex and function concertedly to control autophagy. Optineurin (OPTN), implicated genetically in glaucoma and amyotrophic lateral sclerosis, was a recently identified autophagy receptor. Here we report that tumor-suppressor HACE1, a ubiquitin ligase, ubiquitylates OPTN and promotes its interaction with p62/SQSTM1 to form the autophagy receptor complex, thus accelerating autophagic flux. Interestingly, the Lys48-linked polyubiquitin chains that HACE1 conjugates onto OPTN might predominantly target OPTN for autophagic degradation. By demonstrating that the HACE1-OPTN axis synergistically suppresses growth and tumorigenicity of lung cancer cells, our findings may open an avenue for developing autophagy-targeted therapeutic intervention into cancer. |
| 学科主题 | Oncology; Cell Biology |
| 类目[WOS] | Oncology ; Cell Biology |
| 关键词[WOS] | E3 UBIQUITIN LIGASES ; HECT FAMILY ; P62 ; PROTEIN ; CANCER ; TUMORIGENESIS ; DEGRADATION ; MUTATIONS ; STRESS ; PATHWAY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000339305200015 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/120]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, ZZ,Chen, P,Gao, H,et al. Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression[J]. CANCER CELL,2014,26(1):106-120. |
| APA | Liu, ZZ.,Chen, P.,Gao, H.,Gu, Y.,Yang, J.,...&Hu, RG.(2014).Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression.CANCER CELL,26(1),106-120. |
| MLA | Liu, ZZ,et al."Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression".CANCER CELL 26.1(2014):106-120. |
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