Protein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons
文献类型：期刊论文
| 作者 | Huang, W; She, L; Chang, XY; Yang, RR; Wang, L; Ji, HB; Jiao, JW; Poo, MM |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2014 |
| 卷号 | 111期号:1页码:469-474 |
| 关键词 | adult neurogenesis neuronal polarization Golgi deployment |
| 通讯作者 | Poo, MM (reprint author), Chinese Acad Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai 200031, Peoples R China.,mpoo@ion.ac.cn |
| 英文摘要 | Adult-born granule cells in the dentate gyrus of the rodent hippocampus are important for memory formation and mood regulation, but the cellular mechanism underlying their polarized development, a process critical for their incorporation into functional circuits, remains unknown. We found that deletion of the serine-threonine protein kinase LKB1 or overexpression of dominant-negative LKB1 reduced the polarized initiation of the primary dendrite from the soma and disrupted its oriented growth toward the molecular layer. This abnormality correlated with the dispersion of Golgi apparatus that normally accumulated at the base and within the initial segment of the primary dendrite, andwas mimicked by disrupting Golgi organization via altering the expression of Golgi structural proteins GM130 or GRASP65. Thus, besides its known function in axon formation in embryonic pyramidal neurons, LKB1 plays an additional role in regulating polarized dendrite morphogenesis in adult-born granule cells in the hippocampus. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | NEWLY GENERATED NEURONS ; PATTERN SEPARATION ; SECRETORY TRAFFICKING ; ELEGANS EMBRYOS ; SAD KINASES ; STEM-CELLS ; NEUROGENESIS ; ACTIVATION ; PATHWAY ; STRAD |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000329350700108 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/127]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Huang, W,She, L,Chang, XY,et al. Protein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014,111(1):469-474. |
| APA | Huang, W.,She, L.,Chang, XY.,Yang, RR.,Wang, L.,...&Poo, MM.(2014).Protein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,111(1),469-474. |
| MLA | Huang, W,et al."Protein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111.1(2014):469-474. |
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