Integrative Genomic Analysis Reveals a High Frequency of LKB1 Genetic Alteration in Chinese Lung Adenocarcinomas
文献类型：期刊论文
| 作者 | Fang, R; Zheng, C; Sun, YH; Han, XK; Gao, B; Li, CG; Liu, HY; Wong, KK; Liu, XY; Chen, HQ |
| 刊名 | JOURNAL OF THORACIC ONCOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 9期号:2页码:254-258 |
| 关键词 | Liver kinase B1 Lung cancer Multiplex ligation-dependent probe amplification |
| 通讯作者 | Ji, HB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,hbji@sibcb.ac.cn |
| 英文摘要 | Liver kinase B1 (LKB1) genetic alteration in lung cancer involves not only point mutations and small deletion of several base pairs but also exonic loss. However, most of recent studies in LKB1 gene status only focus on point mutations and small deletion, and thus may underestimate the actual frequency of LKB1 genetic alteration in lung cancer. Thus, an integrative analysis of LKB1 genetic alteration is timely and important for providing a better estimate for the incidence of genetic alterations in this important tumor suppressor gene. One hundred and seven lung adenocarcinomas with more than 70% tumor have been analyzed for mutation of LKB1 as well as LKB1 large deletions detection by using multiplex ligation-dependent probe amplification analysis. These samples were also analyzed for EGFR, KRAS, HER2, BRAF, ALK, ROS1, and RET status in stepwise method. Among 107 lung adenocarcinomas analyzed, 29 (27.1%) harbored LKB1 genetic alteration. Twenty-three (21.5%) harbored LKB1 large exonic deletions and eight (7.48%) had LKB1 points mutations, two samples harbored both LKB1 large exonic deletions and point mutations. Eighty-seven samples (81.31%) harbored known driver mutations and 20 samples (18.69%) had no identifiable driver mutations. A high rate of LKB1 genetic alteration in Chinese lung adenocarcinomas is revealed by the integrative analysis of point mutation and exonic deletion. Moreover, LKB1 genetic alterations are concurrent with EGFR, KRAS, HER2, and CD74-ROS fusions. |
| 学科主题 | Oncology ; Respiratory System |
| 类目[WOS] | Oncology ; Respiratory System |
| 关键词[WOS] | PEUTZ-JEGHERS-SYNDROME ; CANCER PATIENTS ; MUTATIONS ; SPECTRUM ; LKB1/STK11 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330078100024 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/149]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Fang, R,Zheng, C,Sun, YH,et al. Integrative Genomic Analysis Reveals a High Frequency of LKB1 Genetic Alteration in Chinese Lung Adenocarcinomas[J]. JOURNAL OF THORACIC ONCOLOGY,2014,9(2):254-258. |
| APA | Fang, R.,Zheng, C.,Sun, YH.,Han, XK.,Gao, B.,...&Ji, HB.(2014).Integrative Genomic Analysis Reveals a High Frequency of LKB1 Genetic Alteration in Chinese Lung Adenocarcinomas.JOURNAL OF THORACIC ONCOLOGY,9(2),254-258. |
| MLA | Fang, R,et al."Integrative Genomic Analysis Reveals a High Frequency of LKB1 Genetic Alteration in Chinese Lung Adenocarcinomas".JOURNAL OF THORACIC ONCOLOGY 9.2(2014):254-258. |
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