Thymine DNA glycosylase promotes transactivation of beta-catenin/TCFs by cooperating with CBP
文献类型：期刊论文
| 作者 | Jia, YY; Nie, F; Du, AY; Chen, ZC; Qin, YB; Huang, T; Song, XM; Li, L |
| 刊名 | JOURNAL OF MOLECULAR CELL BIOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 6期号:3页码:231-239 |
| 关键词 | TDG TCF CBP Wnt signaling transactivation |
| 通讯作者 | Li, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,lli@sibs.ac.cn |
| 英文摘要 | Thymine DNA glycosylase (TDG), an enzyme that initiates the repair of G/T and G/U mismatches, has been lately found crucial in embryonic development to maintain epigenetic stability and facilitate the active DNA demethylation. Here we report a novel role of TDG in Wnt signaling as a transcriptional coactivator of beta-catenin/TCFs complex. Our data show that TDG binds to the transcriptional factor family LEF1/TCFs and potentiates beta-catenin/TCFs transactivation, while TDG depletion suppresses Wnt3a-stimulated reporter activity or target gene transcription. Next, we show that CBP, a known coactivator, is also required for TDG function through forming a cooperative complex on target promoters. Moreover, there is an elevation of TDG levels in human colon cancer tissue, and knockdown of TDG inhibits proliferation of the colon cells. Overall, our results reveal that TDG, as a new coactivator, promotes beta-catenin/TCFs transactivation and functionally cooperates with CBP in canonical Wnt signaling. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | WNT SIGNALING PATHWAY ; BASE-EXCISION-REPAIR ; ARMADILLO/BETA-CATENIN ; GENE-EXPRESSION ; TRANSCRIPTION ; METHYLATION ; ACTIVATION ; CANCER ; ACETYLTRANSFERASES ; PROLIFERATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337065700007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/157]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Jia, YY,Nie, F,Du, AY,et al. Thymine DNA glycosylase promotes transactivation of beta-catenin/TCFs by cooperating with CBP[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2014,6(3):231-239. |
| APA | Jia, YY.,Nie, F.,Du, AY.,Chen, ZC.,Qin, YB.,...&Li, L.(2014).Thymine DNA glycosylase promotes transactivation of beta-catenin/TCFs by cooperating with CBP.JOURNAL OF MOLECULAR CELL BIOLOGY,6(3),231-239. |
| MLA | Jia, YY,et al."Thymine DNA glycosylase promotes transactivation of beta-catenin/TCFs by cooperating with CBP".JOURNAL OF MOLECULAR CELL BIOLOGY 6.3(2014):231-239. |
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