Ionic protein lipid interaction at the plasma membrane: what can the charge do?
文献类型：期刊论文
| 作者 | Li, LY; Shi, XS; Guo, XD; Li, H; Xu, CQ |
| 刊名 | TRENDS IN BIOCHEMICAL SCIENCES
 |
| 出版日期 | 2014 |
| 卷号 | 39期号:3页码:130-140 |
| 关键词 | acidic phospholipids ionic protein-lipid interaction Ca2+ |
| 通讯作者 | Xu, CQ (reprint author), Chinese Acad Sci, Natl Ctr Prot Sci Shanghai, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol,State Key Lab Mol Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,cqxu@sibcb.ac.cn |
| 英文摘要 | Phospholipids are the major components of cell membranes, but they have functional roles beyond forming lipid bilayers. In particular, acidic phospholipids form microdomains in the plasma membrane and can ionically interact with proteins via polybasic sequences, which can have functional consequences for the protein. The list of proteins regulated by ionic protein-lipid interaction has been quickly expanding, and now includes membrane proteins, cytoplasmic soluble proteins, and viral proteins. Here we review how acidic phospholipids in the plasma membrane regulate protein structure and function via ionic interactions, and how Ca2+ regulates ionic protein-lipid interactions via direct and indirect mechanisms. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | CELL-RECEPTOR ZETA ; K+ CHANNEL KIR2.2 ; PHOSPHATIDIC-ACID ; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE ; CRYSTAL-STRUCTURE ; BINDING DOMAIN ; CYTOPLASMIC DOMAIN ; SUBUNIT CONTAINS ; PHOSPHOLIPASE-C ; MODEL MEMBRANES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000332752400004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/164]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Li, LY,Shi, XS,Guo, XD,et al. Ionic protein lipid interaction at the plasma membrane: what can the charge do?[J]. TRENDS IN BIOCHEMICAL SCIENCES,2014,39(3):130-140. |
| APA | Li, LY,Shi, XS,Guo, XD,Li, H,&Xu, CQ.(2014).Ionic protein lipid interaction at the plasma membrane: what can the charge do?.TRENDS IN BIOCHEMICAL SCIENCES,39(3),130-140. |
| MLA | Li, LY,et al."Ionic protein lipid interaction at the plasma membrane: what can the charge do?".TRENDS IN BIOCHEMICAL SCIENCES 39.3(2014):130-140. |
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