SMAC-armed vaccinia virus induces both apoptosis and necroptosis and synergizes the efficiency of vinblastine in HCC
文献类型：期刊论文
| 作者 | Pan, Q; Huang, YY; Chen, LY; Gu, JF; Zhou, XM |
| 刊名 | HUMAN CELL
 |
| 出版日期 | 2014 |
| 卷号 | 27期号:4页码:162-171 |
| 关键词 | Vaccinia virus SMAC/DIABLO Apoptosis Necroptosis Ripoptosome Vinblastine |
| 通讯作者 | Zhou, XM (reprint author), Zhejiang Sci Tech Univ, Xinyuan Inst Med & Biotechnol, Room 217,Bldg No 6, Hangzhou 310018, Zhejiang, Peoples R China.,zhouxiumei824@163.com |
| 英文摘要 | Hepatocellular carcinoma (HCC) has particularly high incidence rate in Asia and its resistance to the chemotherapeutic drugs and cell death make it intractable. Vaccinia virus (VV) is a potential vehicle and has been widely used in cancer therapy. SMAC/DIABLO is a critical factor in activating caspases and eliminating inhibition of IAPs when the programmed cell death is promoted. In this study, we constructed a tumor-targeted vaccinia virus carrying SMAC/DIABLO gene that was knocked in the region of viral thymidine kinase gene (VV-SMAC). Our results showed that VV-SMAC efficiently infected and destroyed HCC cells via triggering both caspase-dependent apoptosis and necroptosis with depletion of IAPs. Furthermore, ripoptosome, a prerequisite complex of necroptosis, was assembled and induced by VV-SMAC. In addition, the combination of VV-SMAC and vinblastine represented a synergistic effect on HCC cells. In summary, our data suggest that VV-SMAC is a potential candidate and combination of VV-SMAC and vinblastine may provide a new avenue in treatment of HCC. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | ONCOLYTIC ADENOVIRUS ; CANCER ; SMAC/DIABLO ; CARCINOMA ; CELLS ; RIPOPTOSOME ; DEGRADATION ; HALLMARKS ; PROTEINS ; POXVIRUS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000347016000003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/171]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Pan, Q,Huang, YY,Chen, LY,et al. SMAC-armed vaccinia virus induces both apoptosis and necroptosis and synergizes the efficiency of vinblastine in HCC[J]. HUMAN CELL,2014,27(4):162-171. |
| APA | Pan, Q,Huang, YY,Chen, LY,Gu, JF,&Zhou, XM.(2014).SMAC-armed vaccinia virus induces both apoptosis and necroptosis and synergizes the efficiency of vinblastine in HCC.HUMAN CELL,27(4),162-171. |
| MLA | Pan, Q,et al."SMAC-armed vaccinia virus induces both apoptosis and necroptosis and synergizes the efficiency of vinblastine in HCC".HUMAN CELL 27.4(2014):162-171. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。