Activation of Vascular Endothelial Growth Factor Receptor-3 in Macrophages Restrains TLR4-NF-kappa B Signaling and Protects against Endotoxin Shock
文献类型：期刊论文
| 作者 | Zhang, YB; Lu, Y; Ma, L; Cao, XD; Xiao, J; Chen, JX; Jiao, SZ; Gao, YZ; Liu, C; Duan, ZJ |
| 刊名 | IMMUNITY
 |
| 出版日期 | 2014 |
| 卷号 | 40期号:4页码:501-514 |
| 通讯作者 | Wei, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,binweiwhy@gmail.com ; hongyanwang@sibcb.ac.cn |
| 英文摘要 | Toll-like receptors (TLRs) are critical in mediating innate immune responses against infections. However, uncontrolled TLR-triggered inflammation is associated with endotoxin shock. To better understand the homeostatic mechanisms induced by TLR4 signaling, we screened a group of key cytokines, chemokines, growth factors, and their receptors for bacteria-or LPS-induced expression. The surface vascular endothelial growth factor receptor-3 (VEGFR-3) and its ligand VEGF-C were upregulated in macrophages. VEGFR-3 ligation by VEGF-C significantly attenuated proinflammatory cytokine production. Notably, ablation of the ligand-binding domain or tyrosine kinase activity of VEGFR-3 rendered mice more sensitive to septic shock. VEGFR-3 restrained TLR4-NF-kappa B activation by regulating the PI3-kinase-Akt signaling pathway and SOCS1 expression. Aside from targeting lymphatic vessels, we suggest a key role of VEGFR-3 on macrophages to prevent infections that is complicated with lymphoedema. Thus, VEGFR-3-VEGF-C signaling represents a "self-control" mechanism during antibacterial innate immunity. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | PHOSPHOINOSITIDE 3-KINASE P110-DELTA ; NEGATIVE REGULATION ; LYMPHATIC VESSELS ; FOXP3 EXPRESSION ; SEVERE SEPSIS ; CUTTING EDGE ; CELLS ; LYMPHANGIOGENESIS ; ANGIOGENESIS ; VEGF |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000334849400009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/176]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, YB,Lu, Y,Ma, L,et al. Activation of Vascular Endothelial Growth Factor Receptor-3 in Macrophages Restrains TLR4-NF-kappa B Signaling and Protects against Endotoxin Shock[J]. IMMUNITY,2014,40(4):501-514. |
| APA | Zhang, YB.,Lu, Y.,Ma, L.,Cao, XD.,Xiao, J.,...&Wang, HY.(2014).Activation of Vascular Endothelial Growth Factor Receptor-3 in Macrophages Restrains TLR4-NF-kappa B Signaling and Protects against Endotoxin Shock.IMMUNITY,40(4),501-514. |
| MLA | Zhang, YB,et al."Activation of Vascular Endothelial Growth Factor Receptor-3 in Macrophages Restrains TLR4-NF-kappa B Signaling and Protects against Endotoxin Shock".IMMUNITY 40.4(2014):501-514. |
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